Formulation and antibacterial activity of silver nanoparticle hydrogels
Other Title(s)
تركيب و نشاط جزيئات الفضة النانوية المضاد للبكتيريا في تركيبات الهيدروجيل
Dissertant
Thesis advisor
Abu Dawlah, Suha Mujahid
al-Kilani, Ala al-Din M.
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2018
English Abstract
The antibacterial activity of silver nanoparticles (AgNPs ) is well documented.
AgNPs have a broad spectrum activity against gram negative and gram positive bacteria.
Most reports evaluated the antibacterial activity of AgNPs in suspensions and not in clinically relevant vehicles such as hydrogels.
In this work we prepared a library of monodispersed AgNPs with various sizes and we described the successful incorporation of these nanoparticles into two type of hydrogels: Carbopol ( represented anionic polymer ) and Pluronic ( represented nonionic polymer ).
AgNPs exhibit excellent colloidal stability in both hydrogels upon storage.
However, aggregation occurred upon contact with Tryptic soy agar ( bacterial growth media ) for carbopol hydrogels but not for pluronic hydrogels.
AgNPs showed different antibacterial activity in both hydrogels, with a common trend supported higher activity for AgNPs with smaller size.
This work highlighted the importance of considering nanoparticles size and the type of gelling agent when formulations AgNPs hydrogel which affect their colloidal stability and antibacterial activity.
Main Subjects
Topics
No. of Pages
67
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Materials and methodology.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion.
References.
American Psychological Association (APA)
al-Urud, Amani Adil Umar. (2018). Formulation and antibacterial activity of silver nanoparticle hydrogels. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832825
Modern Language Association (MLA)
al-Urud, Amani Adil Umar. Formulation and antibacterial activity of silver nanoparticle hydrogels. (Master's theses Theses and Dissertations Master). Isra University. (2018).
https://search.emarefa.net/detail/BIM-832825
American Medical Association (AMA)
al-Urud, Amani Adil Umar. (2018). Formulation and antibacterial activity of silver nanoparticle hydrogels. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-832825
Language
English
Data Type
Arab Theses
Record ID
BIM-832825
