Effects of dose amount for antiepileptic drugs on lipid profile of male rats (rattus norvegicus)
Other Title(s)
تأثير كمية الجرعة للأدوية المضادة للصرع في مستوى الدهون لذكور الجرذان المختبرية
Source
Issue
Vol. 6, Issue 2 (30 Jun. 2017), pp.90-95, 6 p.
Publisher
University of Thi-Qar College of Science
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
The present study aimd to estimate the changes in lipid profile depend on dosage amount of two AEDs ,Phenytoin (PHT) and Carbamazepine (CBZ) , and make a comparison between them in rats.
A 30 healthy male Wistar rats (150-200 g) ( subdivide to five groups ) first group was control , the second and third groups received (50 mg\kg and 100 mg\kg) of Phenytoin respectively, fourth and fifth groups received (25 mg/kg and 50 mg/kg) of Carbamazepine respectively.
Serum total cholesterol (TC), triglycerides (TGs) and High-density lipoprotein (HDL) levels were measured after 20 days period of treating, Low-density lipoprotein (LDL) and Very low-density lipoprotein (VLDL) was calculated also.
Our data revealed that, the administration of PHT (50 mg\kg) and CBZ (25 mg\kg) didn’t affect serum lipid profile significantly compared to control group in male rats except the levels of VLDL in CBZ (25 mg\kg) group which increased significantly (p-value <0.05) compared to control group, on the other hand we found that the administration of double dose (PHT 100 mg\kg and CBZ 50 mg/kg) in group3 and group5 respectively caused a significant increase in TC, TGs, LDL and VLVL in both groups compare to control group.
According to our results we conclude that the doubling the dose of CBZ and PHT cause an increase in cholesterol, TGs, LDL and VLDL and switching from CBZ and PHT to another drugs or decrease the dosage could contributes to avoid effects on the lipid metabolism profile of patients with chronic epilepsy.
American Psychological Association (APA)
Abbas, Abbas Muhsin. 2017. Effects of dose amount for antiepileptic drugs on lipid profile of male rats (rattus norvegicus). Journal of Thi-Qar Science،Vol. 6, no. 2, pp.90-95.
https://search.emarefa.net/detail/BIM-834293
Modern Language Association (MLA)
Abbas, Abbas Muhsin. Effects of dose amount for antiepileptic drugs on lipid profile of male rats (rattus norvegicus). Journal of Thi-Qar Science Vol. 6, no. 2 (Jun. 2017), pp.90-95.
https://search.emarefa.net/detail/BIM-834293
American Medical Association (AMA)
Abbas, Abbas Muhsin. Effects of dose amount for antiepileptic drugs on lipid profile of male rats (rattus norvegicus). Journal of Thi-Qar Science. 2017. Vol. 6, no. 2, pp.90-95.
https://search.emarefa.net/detail/BIM-834293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 93-95
Record ID
BIM-834293