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استقصاء التعبير عن بروتين ال c-Flip نسيجيا لدى مرضى مشخصين بسرطان القولون و المستقيم و علاقته بدرجة الورم
Other Title(s)
Investigation of c-Flip protein histologically in patients diagnosed with colorectal cancer and its association with tumour grade
Joint Authors
زيتون، المعتصم بالله
بدران، يارا
مدنية، عمار
أيمن علي
Source
Issue
Vol. 8, Issue 5 (31 Jan. 2018)6 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2018-01-31
Country of Publication
Syria
No. of Pages
6
Main Subjects
Abstract EN
Colorectal cancer is considered to be the most common cancer among gastrointestinal tract, but it could be curable when diagnosed early.
Recently, cellular FLICE-like inhibitory protein (c-FLIP) has been identified as an endogenous inhibitor of Fas, and its altered high expression has a suspected association with tumour development or progression.
During tumour progression, cancer cells use diverse mechanisms to escape from apoptosis inducing stimuli.
Substantial numbers of colon cancer cells have been observed to express Fas/Fas ligand, but are resistant to Fas-mediated apoptosis, suggesting that colonic tumours might develop specific mechanisms to overcome Fas-mediated apoptosis, through interaction with DISC.
In an effort to investigate the prevalence of c-FLIP alterations in colon carcinomas and their possible implications for the progression of colon and rectal cancers, c-FLIP expression at protein levels, was analyzed in 24 adenocarcinomas samples of Syrian patients diagnosed with colorectal carcinomas, by immunohistochemistry.
The expression of c-FLIP were over expressed in 41.66% of the samples (p<0.05).
This result strongly suggest, that abnormal over expression of cFLIP is a frequent event in colon carcinomas and might contribute to in vivo tumour transformation, but we did not find any association between c-FLIP expression and tumours grade.
American Psychological Association (APA)
بدران، يارا ومدنية، عمار وأيمن علي وزيتون، المعتصم بالله. 2018. استقصاء التعبير عن بروتين ال c-Flip نسيجيا لدى مرضى مشخصين بسرطان القولون و المستقيم و علاقته بدرجة الورم. مجلة التشخيص المخبري،مج. 8، ع. 5.
https://search.emarefa.net/detail/BIM-835792
Modern Language Association (MLA)
بدران، يارا....[و آخرون]. استقصاء التعبير عن بروتين ال c-Flip نسيجيا لدى مرضى مشخصين بسرطان القولون و المستقيم و علاقته بدرجة الورم. مجلة التشخيص المخبري مج. 8، ع. 5 (كانون الثاني 2018).
https://search.emarefa.net/detail/BIM-835792
American Medical Association (AMA)
بدران، يارا ومدنية، عمار وأيمن علي وزيتون، المعتصم بالله. استقصاء التعبير عن بروتين ال c-Flip نسيجيا لدى مرضى مشخصين بسرطان القولون و المستقيم و علاقته بدرجة الورم. مجلة التشخيص المخبري. 2018. مج. 8، ع. 5.
https://search.emarefa.net/detail/BIM-835792
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية
Record ID
BIM-835792