استقصاء التعبير عن بروتين ال c-Flip نسيجيا لدى مرضى مشخصين بسرطان القولون و المستقيم و علاقته بدرجة الورم

Abstract EN

Colorectal cancer is considered to be the most common cancer among gastrointestinal tract, but it could be curable when diagnosed early.

Recently, cellular FLICE-like inhibitory protein (c-FLIP) has been identified as an endogenous inhibitor of Fas, and its altered high expression has a suspected association with tumour development or progression.

During tumour progression, cancer cells use diverse mechanisms to escape from apoptosis inducing stimuli.

Substantial numbers of colon cancer cells have been observed to express Fas/Fas ligand, but are resistant to Fas-mediated apoptosis, suggesting that colonic tumours might develop specific mechanisms to overcome Fas-mediated apoptosis, through interaction with DISC.

In an effort to investigate the prevalence of c-FLIP alterations in colon carcinomas and their possible implications for the progression of colon and rectal cancers, c-FLIP expression at protein levels, was analyzed in 24 adenocarcinomas samples of Syrian patients diagnosed with colorectal carcinomas, by immunohistochemistry.

The expression of c-FLIP were over expressed in 41.66% of the samples (p<0.05).

This result strongly suggest, that abnormal over expression of cFLIP is a frequent event in colon carcinomas and might contribute to in vivo tumour transformation, but we did not find any association between c-FLIP expression and tumours grade.