دراسة مستويات بعض السيتوكينات و الإريثروبويتين المرافقة لفقر الدم لدى المصابين بأدواء الغراء

Abstract EN

Patients of collagen's diseases suffer from associated chronic anemia.

So the objective of this study was to highlight the levels of Erythropoietin (EPO), L-1? and IL-6 cytokines in patients of collagen's diseases, and to investigate their role in associated anemia.

The study included 88 individuals: 24 Rheumatoid Arthritis (RA) patients, 37 Systemic Lupus Erythematosus (SLE) patients, and 27 healthy controls.

IL-1?, IL-6, and EPO were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) and the hemoglobin were measured by performing Complete Blood Count CBC.

The levels of IL-1?, IL-6, and EPO in SLE and RA groups were significantly higher than those of the control group.

We also observed a significant increase in IL-6 at RA patients higher than those in SLE patients.

A statistically significant decrease in the hemoglobin values of the two collagen's diseases groups as compared to control group was observed with inverse relation to EPO elevation.

When the two groups of collagen diseases were divided into patients with anemia and others without anemia, in order to follow up and study the relevant parameters in anemia, the difference was not statistically significant for IL-6 and IL-1?.

Statistical significance of EPO levels was observed between the two groups of patients with collagen diseases with anemia and those with non-anemic disease.

EPO levels in patients with anemia were higher than in the other group.

As a conclusion, IL-1?, IL-6, and EPO are significantly higher in patients of collagen's diseases, and IL-6 in RA patients is significantly higher.

There was no significant difference in IL-1? and IL-6 values among patients with anemic and non-anemic collagen diseases, while we found a marked increase in EPO values in collagen's diseases patients with anemia.