Influence of aqueous extract the pomegranate peel on healing of gastric ulcer in experimental rats

Abstract EN

In the present study the antiulcerogenic effects of aqueous extract of Pomegranate Peel (PP), was tested on male Sprague Dawley rats.

Oral treatment with PP (200, 400 and 600 mg/kg) for 21 days protected the gastric mucosa against the damage induced by aspirin (200mg/kg).

Anti-ulcer activity of PP was evaluated by measuring the Ulcer Index (UI), Volume of Gastric Guice (VGJ), PH of the gastric fluid and histopathologic changes .The best results were found in a dosage of 600 mg/kg of PP, which showed significant inhibition of UI (1.32±0.05) and VGJ (2.3±0.01ml), as well as showed significant increase of pH (4.09±0.07) in comparison with aspirin induced gastric ulcer group.

Also the high dose of pp markedly reduced the severity of inflammatory reactions in lamina propria and muscularis in fore and glandular stomach.

From the preliminary finding of our study it was concluded that the PP has a significant ulcer healing property.

Further investigations are needed to fully understand the mode of action of the active constituents and to fully exploit pomegranate’s preventive and therapeutic potential.