The value of endoscopic biopsies from first and second parts of duodenum in the diagnosis of celiac disease in correlation with a serological test
Joint Authors
Strak, Sarkis K.
al-Namil, Sura A.
Hashim, Zahran A.
Jazi, Wasan M.
Source
Issue
Vol. 23, Issue 2 (31 Dec. 2017), pp.34-39, 6 p.
Publisher
University of Basrah College of Medicine
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Celiac disease is a chronic immune-mediated enteropathy of the small intestine caused by environmental exposure to gluten in genetically susceptible individuals.
This study was conducted to evaluate and correlate the serological with histopathological findings of duodenal biopsies for the diagnosis of celiac disease.
Sixty-eight patients, 40 (59 %) females whose ages ranged from 13-75 year (mean age 36.4 years), and 28 (41 %) males whose ages ranged from 13-65 year (mean age 37.8 years), with symptoms of chronic diarrhea, weight loss, bloating and unexplained iron deficiency anemia, were tested for anti-tissue transglutaminase IgA tTG, and correlated with histopathological findings of duodenal biopsies obtained from 1st and 2nd parts according to modified Marsh's classification.
Histopathological findings from the 1st and 2nd duodenal parts were also compared with each other.
The results of the 68 patients who were enrolled in the study showed that : 24 (35.3 %) patients tested positive for anti-tissue transglutaminase (titer > 18U / ml), 37(55.8 %) patients had positive histopathological changes (stage I–III).
Twenty-three (33.8%) patients who had both positive anti tTG and histopathological changes were classified as a celiac disease.
The sensitivity of 1st and 2nd parts of duodenal biopsies in detecting celiac disease were 83.7 % and 100 % respectively.
In conclusion; the histopathological changes from the 1st and 2nd parts of duodenum in detecting celiac disease were equally representative especially in stage IIIa, b, and c.
American Psychological Association (APA)
Hashim, Zahran A.& al-Namil, Sura A.& Jazi, Wasan M.& Strak, Sarkis K.. 2017. The value of endoscopic biopsies from first and second parts of duodenum in the diagnosis of celiac disease in correlation with a serological test. Basrah Journal of Surgery،Vol. 23, no. 2, pp.34-39.
https://search.emarefa.net/detail/BIM-837836
Modern Language Association (MLA)
Hashim, Zahran A.…[et al.]. The value of endoscopic biopsies from first and second parts of duodenum in the diagnosis of celiac disease in correlation with a serological test. Basrah Journal of Surgery Vol. 23, no. 2 (Dec. 2017), pp.34-39.
https://search.emarefa.net/detail/BIM-837836
American Medical Association (AMA)
Hashim, Zahran A.& al-Namil, Sura A.& Jazi, Wasan M.& Strak, Sarkis K.. The value of endoscopic biopsies from first and second parts of duodenum in the diagnosis of celiac disease in correlation with a serological test. Basrah Journal of Surgery. 2017. Vol. 23, no. 2, pp.34-39.
https://search.emarefa.net/detail/BIM-837836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39
Record ID
BIM-837836