The survey of Her2 neu expression and it’s correlation with some pathological factors in urothelial bladder tumors
Joint Authors
Danaei, Samani
Madani, Sayyid Hamid
Khazaei, Sedigheh
Izadi, Babak
Salih, Elahe
Sajadimajd, Soraya
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 2 (28 Feb. 2018), pp.1-5, 5 p.
Publisher
Publication Date
2018-02-28
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Abstract EN
Background: Overexpression of human epidermal growth factor receptor 2 (Her2) protein has been shown in a variety of human malignant tumors.
In some of these tumors, such as breast carcinoma, targeted anti-Her2 therapy has been considered as a promising therapeutic strategy.
Objectives: The aim of this analytic descriptive study was to evaluate the immunohistochemical expression of Her2 and its relation to grade and muscular invasion of urothelial bladder tumor.
Methods: In this descriptive-analytic study, 179 paraffin-embedded tissue blocks from patients with urothelial bladder tumors were selected for immunohistochemistry (IHC) analysis using antibodies against Her2.
IHC staining was evaluated according to the same criteria of breast carcinoma.
Results: Her2 over expression was detected in 49 patients (27.4%) and was significantly associated with high tumor grade and bladder muscular involvement (P < 0.001).
Conclusions: Her2/neu over expression is associated with aggressive behavior of urothelial bladder tumors.
Assessment of Her2 status could be helpful to identify patients with a high probability of disease progression.
Anti-Her2 therapy could be used in urothelial bladder cancers, however, this issue needs further studies.
American Psychological Association (APA)
Danaei, Samani& Madani, Sayyid Hamid& Khazaei, Sedigheh& Izadi, Babak& Salih, Elahe& Sajadimajd, Soraya. 2018. The survey of Her2 neu expression and it’s correlation with some pathological factors in urothelial bladder tumors. Iranian Red Crescent Medical Journal،Vol. 20, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-840430
Modern Language Association (MLA)
Danaei, Samani…[et al.]. The survey of Her2 neu expression and it’s correlation with some pathological factors in urothelial bladder tumors. Iranian Red Crescent Medical Journal Vol. 20, no. 2 (Feb. 2018), pp.1-5.
https://search.emarefa.net/detail/BIM-840430
American Medical Association (AMA)
Danaei, Samani& Madani, Sayyid Hamid& Khazaei, Sedigheh& Izadi, Babak& Salih, Elahe& Sajadimajd, Soraya. The survey of Her2 neu expression and it’s correlation with some pathological factors in urothelial bladder tumors. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 2, pp.1-5.
https://search.emarefa.net/detail/BIM-840430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5
Record ID
BIM-840430