Expression of transforming growth factor β type I and II receptor in prostate cancer
Other Title(s)
تعبير مستقبلات عامل تحويل النمو (TGF-β) النوع الأول و الثاني في سرطان البروستات
Joint Authors
Zurayji, Hasan Hadi
Ashur, Zaynab Fadil
Baqir, Wasan Abd al-Ilah
Source
Iraqi Journal of Cancer and Medical Genetics
Issue
Vol. 10, Issue 1 (30 Jun. 2017), pp.5-15, 11 p.
Publisher
al-Mustansyriah University Iraqi Centre for Cancer and Medical Genetics Research
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
This study was carried out to establish the correlation between expression of Transforming growth factor beta receptor one (TGF-βRI) and Transforming growth factor beta receptor two (TGF-βRII) and prostate cancer progression, and to establish the role of prostate cancer development.
Immunohistochemistry (IHC) technique was used to detect the level of expression of TGF-βRI and TGF-βRII protein in tissues of patients and healthy control groups.
TGF-βR1 protein was expressed in 3 (18.7%) and 14 (56%) of poorly and moderately differentiated malignancy respectively.
There was significant difference in mean level of TGF-βRI protein expression among all studied groups.
TGF-βRII protein was expressed in 6 (37.5%) and 22 (88%) of poorly and moderately differentiated malignancy respectively, There was significant difference in mean level of TGF-βRII protein expression among all studied groups.
We concluded that there was statistically significant association between the loss of expression of TGF-β1 signaling receptors, especially TGF-βRI, and increasing grades of malignancy in prostate cancer, leading to a more malignant phenotype.
American Psychological Association (APA)
Zurayji, Hasan Hadi& Ashur, Zaynab Fadil& Baqir, Wasan Abd al-Ilah. 2017. Expression of transforming growth factor β type I and II receptor in prostate cancer. Iraqi Journal of Cancer and Medical Genetics،Vol. 10, no. 1, pp.5-15.
https://search.emarefa.net/detail/BIM-844602
Modern Language Association (MLA)
Baqir, Wasan Abd al-Ilah…[et al.]. Expression of transforming growth factor β type I and II receptor in prostate cancer. Iraqi Journal of Cancer and Medical Genetics Vol. 10, no. 1 (2017), pp.5-15.
https://search.emarefa.net/detail/BIM-844602
American Medical Association (AMA)
Zurayji, Hasan Hadi& Ashur, Zaynab Fadil& Baqir, Wasan Abd al-Ilah. Expression of transforming growth factor β type I and II receptor in prostate cancer. Iraqi Journal of Cancer and Medical Genetics. 2017. Vol. 10, no. 1, pp.5-15.
https://search.emarefa.net/detail/BIM-844602
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-844602