Teratogenic effect of levetiracetam drug on the development of the kidney in embryo rat
Joint Authors
al-Ibrahimi, Lamya H. M.
al-Bakri, Nahlah A.
Source
مجلة ابن الهيثم للعلوم الصرفة و التطبيقية
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
English Abstract
The new antiepileptic drugs, levetiracetam (LEV), are used to treat tonic-clonic seizures and myoclonic seizures in adults and children.
Thirty pregnant rats were enrolled, which were divided into two groups A control (10), B treated (20).
Group (A) were given distilled water orally for 15 days of pregnancy period.
The other group was subdivided into two subgroups B1, B2 (each with 10 rats), which were treated with LEV for 14 days for subgroup (B1) and 15 days for the other subgroup (B2).
The drug (350 mg/kg/day) is administered orally.
Based on our results there was damage in the kidney due to the toxicity of the drug.
The histopathological effects are represented by damage of cortical glomeruli in which there were hemorrhage, shrinking, accumulation of glomerular cells, and enlargement of capsular space.
Severe malformations in the kidney were observed when the drug is used constantly during the organogenesis stages of pregnancy
Data Type
Conference Papers
Record ID
BIM-851487
American Psychological Association (APA)
al-Ibrahimi, Lamya H. M.& al-Bakri, Nahlah A.. 2017-12-31. Teratogenic effect of levetiracetam drug on the development of the kidney in embryo rat. International Conference on Biology, Chemistry, Computer Science, Mathematics, and Physics, will take place (2017 : Ibn Al Haitham University of Baghdad, Iraq). . Special issue (2017), pp.31-40.Baghdad Iraq : University of Baghdad College of Education for Pure Science / Ibn al-Haitham.
https://search.emarefa.net/detail/BIM-851487
Modern Language Association (MLA)
al-Ibrahimi, Lamya H. M.& al-Bakri, Nahlah A.. Teratogenic effect of levetiracetam drug on the development of the kidney in embryo rat. . Baghdad Iraq : University of Baghdad College of Education for Pure Science / Ibn al-Haitham. 2017-12-31.
https://search.emarefa.net/detail/BIM-851487
American Medical Association (AMA)
al-Ibrahimi, Lamya H. M.& al-Bakri, Nahlah A.. Teratogenic effect of levetiracetam drug on the development of the kidney in embryo rat. . International Conference on Biology, Chemistry, Computer Science, Mathematics, and Physics, will take place (2017 : Ibn Al Haitham University of Baghdad, Iraq).
https://search.emarefa.net/detail/BIM-851487
