Synthesis, characterization of Chlropheuirainine maleate-molecularly imprinted polymers and their application as sensors for the determination of the drug in some pharmaceutical preparations

Abstract EN

New chlropkeniramine maleate (CPM) selective electrochemical membranes were prepared by using chlrophemramme maleate -molecularly imprinted polymers.

MIP was prepared by bulk polymerization using 2-hydroxyethyl methacrylate (2-HEMA) as monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and a benzoyl peroxide (BPO) as an initiator at 60°C.

Three CPM-MIP electrodes were constructed by using tri-tolyl Phosphate (ToCP), tris (2- ethyl hexyl) Phosphate (TEHP) and tributyl Phospliate (TBP) as plasticizers in PVC matnx.

Electrode parameters including slopes, working concentrations ph.

The mterference effect in the presence of (Na~, Mg+2.

Al~\ Glycine, Alanine.

Arginine and Phenylalanine) was studied using the separated and mixed methods to determine the selectivity coefficient determination.

NIP prepared by using the same composition of MIP molecularly imprinted polymer electrodes except the template (CPM).

The slopes of CMP- MIP are 21.00.

21.50 and 19.08 mV/ decade, linearity range for the electrodes around.

(10'5 - 10'1) M.

the stable at a pH range from 4.0 to 8.5 and lifetime ranged from 30 to 10 days.

The suggested electrodes were successfully applied for the determine of CPM in some pharmaceutical preparations, which were given acceptable accuracy.