Spectrophotometric determination of sulfamethoxazole based on charge-transfer complexation with sodium nitroprusside
Joint Authors
Muhammad, Tariq Y.
Dikran, Sarmad Bahjat
Muhammad, Ala K.
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 30, Issue 3 (31 Dec. 2017), pp.102-113, 12 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2017-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
A simple, accurate and precise spectrophotometric method has been developed for the analysis of sulfamethoxazole (SMZ) in pure form and pharmaceutical preparation.
The method involves a direct charge transfer complexation of sulfamethoxazole (SMZ) with sodium nitroprusside (SNP) in alkaline medium and the presence of hydroxyl amine hydrochloride.
Variables affecting the formation of the formed orange colored complex were optimized following two approaches univariate and central composite experimental design (CCD) multivariate.
Under optimum recommended conditions, the formed complex exhibits Amax at 512 nm and the method conforms Beer's law for SMZ concentration in the range of 5.0-150.0 (µg.mL-1) with molar absorptivity 1.139*103 L.mol.cm-1, and r = 0.9997.
Analysis of SMZ pharmaceutical dosages shows a good agreement with the real amounts.
American Psychological Association (APA)
Muhammad, Tariq Y.& Dikran, Sarmad Bahjat& Muhammad, Ala K.. 2017. Spectrophotometric determination of sulfamethoxazole based on charge-transfer complexation with sodium nitroprusside. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 30, no. 3, pp.102-113.
https://search.emarefa.net/detail/BIM-851845
Modern Language Association (MLA)
Muhammad, Tariq Y.…[et al.]. Spectrophotometric determination of sulfamethoxazole based on charge-transfer complexation with sodium nitroprusside. Ibn al-Haitham Journal for Pure and Applied Science Vol. 30, no. 3 (2017), pp.102-113.
https://search.emarefa.net/detail/BIM-851845
American Medical Association (AMA)
Muhammad, Tariq Y.& Dikran, Sarmad Bahjat& Muhammad, Ala K.. Spectrophotometric determination of sulfamethoxazole based on charge-transfer complexation with sodium nitroprusside. Ibn al-Haitham Journal for Pure and Applied Science. 2017. Vol. 30, no. 3, pp.102-113.
https://search.emarefa.net/detail/BIM-851845
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 108-113
Record ID
BIM-851845