اللوحة التشريحية المرضية الكلوية عند مرضى المتلازمة النفروزية : دراسة 128 حالة في مشفى المواساة الجامعي بدمشق

Abstract EN

Background and Objective: Nephrotic syndrome (NS) is caused by a variety of glomerulopathies.

The Studies in Middle East are few and those in Syria are rare.

The aim of this study is to describe the renal histopathological spectrum of patients with nephrotic syndrome who performed a renal biopsy in our department within the last 6 years.

Methods and Material: This is a cross sectional, descriptive study, included 128 (77 male and 51 female) patients with nephrotic syndrome who attended the Nephrology division at Al Mouassat University Hospital in Damascus between May 2008 and July 2014.

All patients fulfilled the classification criteria for NS.

Results: The mean age was 33.24 ± 13.89 years (range 7-73 years).

More than half of the patients were in third and fourth decades.

Among our patients, the most common cause of nephrotic syndrome was the focal segmental glomerulosclerosis (FSGS) (29.58%) and the membranous glomerulonephritis (MGN) (27.34%), followed by minimal change disease (MCD) (14.84%) and membranoproliferative glomerulonephritis (MPGN) (9.73%).

Lupus nephritis (LN) was seen among younger ages, while renal amyloidosis was most common among older patients.

Conclusion: Focal segmental glomerulosclerosis and membranous glomerulonephritis were the main cause of nephrotic syndrome among our patients, followed by minimal change disease (14.84%) and membranoproliferative glomerulonephritis.

The renal histopathological spectrum of nephrotic syndrome differs between ages