Gdn3+@CNTs-PEG versus gadovist® : in vitro assay
Joint Authors
Abd Allahi, Maryam
Imadi, Ali Rida
Mehri Kakavand, Ghazal
Hasan Zadah, Hadi
Jahanbakhsh, Rouzbeh
Nasr, Rida
Bitarafan Rajabi, Ahmad
Jadidi, Majid
Darbandi Azar, Amir
Source
Issue
Vol. 34, Issue 2 (31 Mar. 2019), pp.147-155, 9 p.
Publisher
Publication Date
2019-03-31
Country of Publication
Oman
No. of Pages
9
Main Subjects
Topics
Abstract EN
Objectives: Carbon nanotubes (CNTs) are allotropes of carbon with a length-todiameter ratio greater than 106 with the potential uses as medical diagnostic or therapeutic agents.
In vitro studies have revealed that gadolinium (Gd) nanoparticlecatalyzed single-walled carbon nanotubes (SWCNTs) possess superparamagnetic properties, which enable them to be used as contrast agents in magnetic resonance imaging (MRI).
Our study synthesized Gd-CNT for use as MRI contrast agents.
Methods: To reduce the toxicity and solubility of CNTs, it was functionalized, and after loading with Gd was coated with polyethylene glycols (PEG).
We then synthesized different concentrations of Gdn 3+@CNTs-PEG and Gadovist® to be evaluated as MRI contrast agents.
Results: The analysis showed that the Gd concentration in Gadovist® was 12.18% higher than synthesized Gdn 3+@CNTs-PEG, but the mean signal intensity of the Gdn 3+@CNTs-PEG was approximately 3.3% times higher than Gadovist®.
Conclusions: Our findings indicate that synthesized Gdn 3+@CNTs-PEG has the potential to be used as an MRI contrast agent in vitro, but in vivo assessment is necessary to determine the bio-distribution, kinetic, and signal enhancement characteristics
American Psychological Association (APA)
Mehri Kakavand, Ghazal& Hasan Zadah, Hadi& Jahanbakhsh, Rouzbeh& Abd Allahi, Maryam& Nasr, Rida& Bitarafan Rajabi, Ahmad…[et al.]. 2019. Gdn3+@CNTs-PEG versus gadovist® : in vitro assay. Oman Medical Journal،Vol. 34, no. 2, pp.147-155.
https://search.emarefa.net/detail/BIM-880724
Modern Language Association (MLA)
Mehri Kakavand, Ghazal…[et al.]. Gdn3+@CNTs-PEG versus gadovist® : in vitro assay. Oman Medical Journal Vol. 34, no. 2 (Mar. 2019), pp.147-155.
https://search.emarefa.net/detail/BIM-880724
American Medical Association (AMA)
Mehri Kakavand, Ghazal& Hasan Zadah, Hadi& Jahanbakhsh, Rouzbeh& Abd Allahi, Maryam& Nasr, Rida& Bitarafan Rajabi, Ahmad…[et al.]. Gdn3+@CNTs-PEG versus gadovist® : in vitro assay. Oman Medical Journal. 2019. Vol. 34, no. 2, pp.147-155.
https://search.emarefa.net/detail/BIM-880724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 153-155
Record ID
BIM-880724