Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries

Joint Authors

Bukiya, Anna N.
Bisen, Shivantika
Dopico, Alex M.
Tobiasz, Ana
Sullivan, Ryan D.
Duncan, Jose
Sullivan, J. Pierce
Davison, Steven
Tate, Danielle L.
Barnett, Stacey
Mari, Giancarlo
Simakova, Maria N.

Source

Journal of Drug and Alcohol Research

Issue

Vol. 8, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.

Publisher

Ashdin Publishing Corporation

Publication Date

2019-12-31

Country of Publication

Egypt

No. of Pages

11

Main Topic

Psychology
Public Health

Abstract EN

Alcohol (ethanol) is one of the most widely consumed drugs.

Alcohol consumption by pregnant women may result in a range of fetal abnormalities termed fetal alcohol spectrum disorders (FASDs).

The cerebrovascular system is emerging as a critical target of alcohol in the developing brain.

We recently showed that three episodes of prenatal alcohol exposure resulting in 80 mg/dL alcohol in maternal blood during mid-pregnancy up-regulated anandamide-induced dilation of fetal cerebral arteries.

Moreover, ethanol dilated fetal cerebral arteries via cannabinoid (CB) receptors.

Whether a critical role of fetal cerebral artery CB system in responses to alcohol was maintained throughout the gestation, remains unknow.

Main methods.

Pregnant baboons (second trimester equivalent) were subjected to three episodes of either alcohol or control drink infusion via gavage.

Cerebral arteries from mothers and near-term female fetuses were in vitro pressurized for diameter monitoring.

Key findings.

Near-term fetal and maternal arteries exhibited similar ability to develop myogenic tone, to constrict in presence of 60 mM KCl, and to respond to 10 μM anandamide.

Fetal and maternal arteries largely failed to dilate in presence of 63 mM ethanol.

No differences were detected between arteries from control and alcohol-exposed baboon donors.

Therefore, previously observed ethanol-induced dilation of fetal cerebral arteries and up-regulation of CB components in response to fetal alcohol exposure during mid-pregnancy was transient and disappeared by near-term.

Significance.

Our findings point at a gestational stage-dependent effect of ethanol on fetal cerebral artery and thus, contribute to our understanding of FASD pathophysiology.

American Psychological Association (APA)

Simakova, Maria N.& Tobiasz, Ana& Sullivan, Ryan D.& Bisen, Shivantika& Duncan, Jose& Sullivan, J. Pierce…[et al.]. 2019. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research،Vol. 8, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-891966

Modern Language Association (MLA)

Simakova, Maria N.…[et al.]. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research Vol. 8 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-891966

American Medical Association (AMA)

Simakova, Maria N.& Tobiasz, Ana& Sullivan, Ryan D.& Bisen, Shivantika& Duncan, Jose& Sullivan, J. Pierce…[et al.]. Gestational age-dependent interplay between endocannabinoid receptors and alcohol in fetal cerebral arteries. Journal of Drug and Alcohol Research. 2019. Vol. 8, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-891966

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 10-11

Record ID

BIM-891966