Protective role of ADA*2 Allele of the adenosine deaminase gene against recurrent spontaneous abortions in Iranian Women
Joint Authors
Najafi, Nuaymah
Ahmadi, Ali Rida
Hajj Husayni, Rida
Khodaverdi, Zubaydah
Muhammadi, Atfah
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 7 (31 Jul. 2019), pp.1-6, 6 p.
Publisher
Publication Date
2019-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: Adenosine deaminase (ADA) is involved in recurrent spontaneous abortion (RSA) while normal pregnancy is defined by suppressed cell-mediated immunity.
Objectives: This study aimed to determine the connection between single nucleotide polymorphism (SNP) G22A and protection against RSA.
Methods: In this analytical case-control study, the allele frequency of ADA G22A gene polymorphism was determined in 113 participants including 50 women with RSA and 63 healthy pregnant women using RFLP-PCR to determine if there is a statistically significant difference in the frequency of ADA genotypes between the patient group and the control group.
Results: The frequency of ADA2/ADA2 (AA) genotype was significantly different between RSA patients and controls (P = 0.004) while no significant differences were identified in the genotype frequency of ADA1/ADA1 (GG) (OR = 0.678; P = 0.228) and ADA1/ADA2 (GA) (OR = 0.976; P = 0.943).
SNP G22A in the ADA gene was associated with the protection against RSA.
The frequency of ADA alleles in RSA patients was compared between the age groups, and the results indicated that the ADA2 (A) allele was associated with protection against RSA in patients aged 35 years or younger (P < 0.0001).
Conclusions: The findings showed that women carrying the ADA*2 allele are protected against RSA.
American Psychological Association (APA)
Najafi, Nuaymah& Ahmadi, Ali Rida& Hajj Husayni, Rida& Khodaverdi, Zubaydah& Muhammadi, Atfah. 2019. Protective role of ADA*2 Allele of the adenosine deaminase gene against recurrent spontaneous abortions in Iranian Women. Iranian Red Crescent Medical Journal،Vol. 21, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-892348
Modern Language Association (MLA)
Najafi, Nuaymah…[et al.]. Protective role of ADA*2 Allele of the adenosine deaminase gene against recurrent spontaneous abortions in Iranian Women. Iranian Red Crescent Medical Journal Vol. 21, no. 7 (Jul. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-892348
American Medical Association (AMA)
Najafi, Nuaymah& Ahmadi, Ali Rida& Hajj Husayni, Rida& Khodaverdi, Zubaydah& Muhammadi, Atfah. Protective role of ADA*2 Allele of the adenosine deaminase gene against recurrent spontaneous abortions in Iranian Women. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-892348
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in .
Record ID
BIM-892348