Biochemical significance of ecto-5’-nucleotidase, xanthine oxidase, and glutathione stransferase determinations in sera of cigarette and water pipe young men smokers

Abstract EN

Background : Apparently, young people begin smoking for different reasons.

for instance, increase the pressure of peers, family attitudes that condone smoking, stress relief, using some drugs or it could be based on many other reasons.

Currently, smoking has been involved as a main responsible for approximately 30 % of all cancer deaths in developed countries.

Materials and Methods : The evaluation was to examine the extent of adverse effects of cigarettes and water pipe (WP) smokers on biochemical characteristics in healthy young men smokers.

Results: The results were shown a significant increase of the measured hematological parameters (white blood cells, hemoglobin, and platelet counts) associated to WP smoker group.

Part of kidney performance was examined under both smoking conditions, and compared to control group, only blood urea levels of WP smoker group were indicated a significant increase (P < 0.05).

On the other hand, the results demonstrated that 5’‑nucleotidase and xanthine oxidase activities were higher in both smoker groups as compared to nonsmoker group, while glutathione S‑transferase was shown a lower activity in WP smokers.

Conclusion: Based on these results, it can be concluded that both types of smoking have influenced many endogenous factors which decreased the cellular protection against free radical attacks and that were obvious through the variability of the measured biological factors under smoking conditions compared to nonsmoking group which easily could be result in a list of diseases usually linked to smoking.