Preparation and characterization of etodolac as a topical nanosponges hydrogel
Other Title(s)
تحضير و تقييم دواء الايتودولاك كإسفنجيات نانوية كمستحلب مائي موضعي
Joint Authors
Abbas, Maysam Muhammad
Rajab, Nawal Ayyash
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 1 (30 Jun. 2019), pp.64-74, 11 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
Nanosponges (NS) of etodolac (ETO) was prepared using the emulsion solvent diffusion method.
Etodolac took as a model drug because of its short half-life, low water solubility; NS is non-irritating, non-mutagenic, nonallergenic and non-toxic suitable to bind to poorly- soluble drugs within the matrix and improve their bioavailability .The effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized.The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug:Polyvinyl alcohol: ethylcellulose in ratio 1:3:2 is the best with smallest particle size 40.2±0.098nm with polydispersibility0.005 and in vitro release 97.6%±0.11, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel
American Psychological Association (APA)
Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. 2019. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.64-74.
https://search.emarefa.net/detail/BIM-894654
Modern Language Association (MLA)
Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.64-74.
https://search.emarefa.net/detail/BIM-894654
American Medical Association (AMA)
Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.64-74.
https://search.emarefa.net/detail/BIM-894654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 72-74
Record ID
BIM-894654