Preparation and characterization of etodolac as a topical nanosponges hydrogel

Other Title(s)

تحضير و تقييم دواء الايتودولاك كإسفنجيات نانوية كمستحلب مائي موضعي

Joint Authors

Abbas, Maysam Muhammad
Rajab, Nawal Ayyash

Source

Iraqi Journal of Pharmaceutical Sciences

Issue

Vol. 28, Issue 1 (30 Jun. 2019), pp.64-74, 11 p.

Publisher

University of Baghdad College of Pharmacy

Publication Date

2019-06-30

Country of Publication

Iraq

No. of Pages

11

Main Subjects

Pharmacology

Abstract EN

Nanosponges (NS) of etodolac (ETO) was prepared using the emulsion solvent diffusion method.

Etodolac took as a model drug because of its short half-life, low water solubility; NS is non-irritating, non-mutagenic, nonallergenic and non-toxic suitable to bind to poorly- soluble drugs within the matrix and improve their bioavailability .The effects of drug: polymer ratio, the effect of level concentration of internal phase and stirring time and other variables that effect on the physical characteristics of NS were investigated and characterized.The selected formula was lyophilized then incorporated into hydrogel ; which also evaluated .The results show that the formulation that contain Drug:Polyvinyl alcohol: ethylcellulose in ratio 1:3:2 is the best with smallest particle size 40.2±0.098nm with polydispersibility0.005 and in vitro release 97.6%±0.11, , ETO NS Carbopol hydrogel produced a significant(p<0.05) improvement of the in vitro release than pure ETO hydrogel

American Psychological Association (APA)

Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. 2019. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 1, pp.64-74.
https://search.emarefa.net/detail/BIM-894654

Modern Language Association (MLA)

Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 1 (2019), pp.64-74.
https://search.emarefa.net/detail/BIM-894654

American Medical Association (AMA)

Abbas, Maysam Muhammad& Rajab, Nawal Ayyash. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 1, pp.64-74.
https://search.emarefa.net/detail/BIM-894654

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 72-74

Record ID

BIM-894654