Evaluation of serum dickkopf‑1 as a novel biomarker for hepatocellular carcinoma
Joint Authors
Hasan, Nifin Abd al-Munim
Muhammad, Ibtisam Faruq
Mahran, Zaynab G.
Abd al-Hamid, Zaynab A.
Ibrahim, Aya M.
Makhluf, Nahid Ahmad
Source
Journal of Current Medical Research and Practice
Issue
Vol. 4, Issue 1 (30 Apr. 2019), pp.91-97, 7 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2019-04-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background Hepatocellular carcinoma (HCC) is a common worldwide cancer.
α‑Fetoprotein (AFP) is a routinely used biomarker for HCC diagnosis, but with reduced clinical applicability due to low sensitivity and specificity.
Dickkopf‑1 (DKK‑1) is vital in the differentiation, survival, apoptosis, and cell death.
DKK‑1 has a potential oncogenic role in carcinogenesis.
Aim In this study, we evaluated the diagnostic and prognostic performance of serum DKK‑1, AFP, and their combination in HCC.
Patient and methods This study was done on 40 HCC patients, 24 liver cirrhosis patients, and 16 age‑matched and sex‑matched healthy controls.
The patients were selected from the Tropical Medicine and Gastroenterology Department, Al‑Rajhi Liver Hospital.
Results The optimum cutoff for DKK‑1 in HCC patients versus liver cirrhosis and control groups was more than 331 pg/ml with a sensitivity of 80.0% and specificity of 87.5%.
The optimum cutoff for AFP was more than 8 IU/ml (sensitivity 77.5%, specificity 85.0%).The combination of the two markers had the best sensitivity (92.5%) in the diagnosis of HCC patients.
Conclusion DKK‑1 levels was significantly higher in newly diagnosed HCC patients than in the nonmalignant control group.
The combination of the two markers (DKK‑1 and AFP) enhanced the sensitivity.
American Psychological Association (APA)
Hasan, Nifin Abd al-Munim& Muhammad, Ibtisam Faruq& Mahran, Zaynab G.& Abd al-Hamid, Zaynab A.& Ibrahim, Aya M.& Makhluf, Nahid Ahmad. 2019. Evaluation of serum dickkopf‑1 as a novel biomarker for hepatocellular carcinoma. Journal of Current Medical Research and Practice،Vol. 4, no. 1, pp.91-97.
https://search.emarefa.net/detail/BIM-895274
Modern Language Association (MLA)
Hasan, Nifin Abd al-Munim…[et al.]. Evaluation of serum dickkopf‑1 as a novel biomarker for hepatocellular carcinoma. Journal of Current Medical Research and Practice Vol. 4, no. 1 (Jan. / Apr. 2019), pp.91-97.
https://search.emarefa.net/detail/BIM-895274
American Medical Association (AMA)
Hasan, Nifin Abd al-Munim& Muhammad, Ibtisam Faruq& Mahran, Zaynab G.& Abd al-Hamid, Zaynab A.& Ibrahim, Aya M.& Makhluf, Nahid Ahmad. Evaluation of serum dickkopf‑1 as a novel biomarker for hepatocellular carcinoma. Journal of Current Medical Research and Practice. 2019. Vol. 4, no. 1, pp.91-97.
https://search.emarefa.net/detail/BIM-895274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 96-97
Record ID
BIM-895274