Clindamycin nano polymers : preparation, characterizations and release study

Dissertant

al-Mahamid, Yusuf Rizq

Thesis advisor

al-Ali, Samir Hasan Husayn

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2019

Arabic Abstract

الأقراص و الكبسولات التقليدية آنية التحرر معدة لتحرر مادة الدواء الفعالة مباشرتا بعد تناوله عن طريق الفم.

هذا النوع من التحرر عموما ينتج عنه امتصاص و بدء تأثير الديناميكا الدوائية المرافقة له بشكل سريع نسيبا.

بدلا عن ذلك، الأدوية المحبة للدهون بطبيعتها لديها تحرر بطيء و بالتالي بدء التأثير لها متأخر، لأن امتصاصها تدريجي نظرا لأن طبيعة ذوبانها بطيئة أو أنها انتقائية الامتصاص خلال القناة الهضمية مؤخرا، الجرعات معدّلة التحرر تم الحصول عليها من خلال تعديل التحرر في الجرعات التقليدية و ذلك عن قصد، لتحقيق التأثير العلاجي الأمثل أو تحسین امتثال المريض لتناول الدواء.

هناك أنواع مختلفة من الجرعات معدلة التحرر تشمل ذات التحرر المؤخر ( على سبيل المثال : الأقراص الملبسة المعوية)، التحرر طويل الأمد، الأقراص المتحللة فمويا المنتجات الدوائية ذات التحرر المطول هي الجرعة التي تخفض تواتر تناول الدواء بشكل مضاعف بالمقارنة مع الدواء التقليدي ذو التحرر الفوري.

تهدف هذه الدراسة لتحضير تركيبة جديدة ومحسنة لدواء الكلينداميسن تتميز بأنها ذات تحرر مطول التأثير من خلال تحميل دواء الكليندامين على البوليمرات النانومترية و ذلك من أجل زيادة زمن بقائها في الجسم.

المركب النانومتري ( CS-Chondro-CLD) تم تحضيره باستخدام بوليمر الكوندريتين ( Chondro)، و بوليمر الكيتوسان ( CS) تمت دراسة المركب النانومتري من حيث الخصائص الفيزيائية والكيميائية، كفاءة التحمل، الأشعة السينية ( XRD) التحليل الطيفي بالأشعة تحت الحمراء ( FT-IR)، المجهر الإلكتروني الماسح ( SEM)، و اخيرا دراسة التحرر.

English Abstract

Conventional immediate release oral tablets and capsules products are formulated to release the active drug immediately after oral administration.

This type of release generally results in relatively rapid drug absorption and onset of accompanying pharmacodynamics effects.

Alternatively, conventional release containing lipophilic drugs, their absorption may be gradual due to slow dissolution in or selective absorption across the GI tract, thus resulting in a delayed onset time.

Recently modified-release dosage forms are deliberately changed from that of a conventional release dosage formulation to achieve a desired therapeutic objective or better patient compliance.

Different types of modified-release drug products include delayed release (eg, enteric coated), extended release, and orally disintegrating tablets.

Extended-release drug products are a dosage form that allow at least a twofold reduction in dosage frequency as compared to that drug presented as a conventional immediate release dosage form.

Examples of extended-release dosage forms include controlled-release, sustained-release, and long-acting drug products.

This study aimed to achieve the optimized preparation of new extended-release formulation of Clindamycin (CLD) via loading of the CLD onto nanopolymers in order to increase the residence time in the body by extended release.

A nanocomposite (CS-Chondro-CLD) was prepared using Chondroitin sulfate (Chondro), and Chitosan (CS) polymer.

The prepared nanocomposite was studied for their physiochemical properties, loading efficiency (LE), X-ray Powder Diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), A scanning electron microscope (SEM), and release.

Full Factorial design was used in this work.

The CS-Chondro nanocomposites were prepared by mixing different mass of CS (50, 100, and 200 mg) with Chondro solutions (50, 100, and 200 mg) under controlled pH of 5.0 using NaOH (0.1%).

The product was centrifuged at 10000 rpm for 15 min and dried.

The same procedure was repeated for the preparation of CS-Chondro-CLD nanocomposites using different concentrations of CLD (75, 150, and 300 mg).

XRD spectra of CS-Chondro and CS-Chondro-CLD showed two peaks at 2θ=22.5o and 40.7o, indicating amorphous forms due to cross-linkage between CS and Chondro.

The FTIR data for all nanocomposites prepared in this work showed the spectra of polymers (CS, and Chondro) as well as the spectra of CLD.

This result indicates the incorporation of CLD in the nanopolymers.

Multiple regression analyses and stepwise method were used in this work to examine the relationship between dependant variables (loading efficiency, particle size and zeta potential) and independent variables with their interactions (concentrations of CS, Chondro and CLD) for all nanocomposites.

Outlier reading was detected by using Mahalanobis distance method.

The data did not contain any outlier values for all experiments.

At LE response, the square (Chondro*Chondro and CLD*CLD) and 2-way interaction (CS*CLD) was excluded from the final equation; whereas other liner, square and 2-way interaction had a significant effect on the LE response.

At size response, 2-way interaction (Chondro*CLD) was excluded from the final equation; whereas other liner, square and 2-way interaction had a significant effect on the size response.

At zeta potential response, 2-way interaction (CS*Chondro) was excluded from the final equation; whereas other liner, square and 2-way interaction had a significant effect on the zeta potential response.

In vitro release study of CLD from its respective nanocomposites was carried out using PBS at pH of 4.8 and 7.4 and showed that the release rate of CLD from the optimized nanocomposites at pH 4.8 start after 10 hours; whereas at pH 7.4 after 2 hours.

Main Subjects

Pharmacology

Topics

No. of Pages

85

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Literature review.

Chapter Three : Methodology.

Chapter Four : Results and discussion.

Chapter Five : Conclusions and recommendation for further.

References.

American Psychological Association (APA)

al-Mahamid, Yusuf Rizq. (2019). Clindamycin nano polymers : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-895807

Modern Language Association (MLA)

al-Mahamid, Yusuf Rizq. Clindamycin nano polymers : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University. (2019).
https://search.emarefa.net/detail/BIM-895807

American Medical Association (AMA)

al-Mahamid, Yusuf Rizq. (2019). Clindamycin nano polymers : preparation, characterizations and release study. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-895807

Language

English

Data Type

Arab Theses

Record ID

BIM-895807