Pattern of peripheral neuropathy in systemic lupus erythematosus : clinical, electrophysiological, and laboratory properties and their association with disease activity

Joint Authors

Ibrahim, Nifin Abd Allah
al-Hadidi, Abir Shawqi
Hasan, Marwah Muhammad
Imam, Muhammad Hasan
Kuraym, Hamdi Khamis

Source

Egyptian Rheumatology and Rehabilitation

Issue

Vol. 46, Issue 4 (31 Dec. 2019), pp.285-298, 14 p.

Publisher

The Egyptian Society for Rheumatology and Rehabilitation

Publication Date

2019-12-31

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Medicine

Topics

Abstract EN

Aim To study clinical, electrophysiological, and laboratory properties of peripheral neuropathy (PN) in systemic lupus erythematosus (SLE) and their association with disease activity.

Patients and methods A total of 30 patients who met the American College of Rheumatology case definition criteria for SLE-PN and 30 age-matched and sex-matched patients with SLE without PN were selected from the Main Alexandria University Hospital Physical Medicine, Rheumatology and Rehabilitation clinic.

Demographic data, SLE-related clinical, laboratory data, Systemic Lupus Activity Measure (SLAM) index, and nerve conduction studies were done.

This case–control study compared clinical and SLE-related features, laboratory, and SLAM index in patients with SLE with PN versus those without neuropathy.

Results The results showed that the most common PN subtype was sensorimotor polyneuropathy which occurred in 18 (60%) patients; the most common PN pathology was axonal degeneration, which occurred 19 (63.3%) patients; and the most common associated nerve entrapment was carpal tunnel syndrome in 10 (33.3%) patients.

In comparison between group I (SLE with PN) and group II (SLE without PN), there was no statistically significant difference between the two groups regarding demographic data, disease duration, and lupus clinical features, except malar rash and lupus nephritis, which showed significant increase in patients with SLE with PN compared with patients with SLE without PN (P=0.003 and P<0.001, respectively).

There was no statistically significant difference among PN subtype groups regarding sex, age, and immunological markers.

Regarding diseases activity, SLAM index showed a significant increase in patients with SLE with PN compared with patients with SLE without PN (P=0.006).

Conclusion The pattern of neuropathy in SLE is mainly axonal.

Moreover, the most common PN subtype is sensorimotor polyneuropathy.

The study suggests significant association of PN in patients with SLE with nephritis, malar rash, and SLAM index.

American Psychological Association (APA)

Imam, Muhammad Hasan& Kuraym, Hamdi Khamis& Hasan, Marwah Muhammad& al-Hadidi, Abir Shawqi& Ibrahim, Nifin Abd Allah. 2019. Pattern of peripheral neuropathy in systemic lupus erythematosus : clinical, electrophysiological, and laboratory properties and their association with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 46, no. 4, pp.285-298.
https://search.emarefa.net/detail/BIM-899744

Modern Language Association (MLA)

Imam, Muhammad Hasan…[et al.]. Pattern of peripheral neuropathy in systemic lupus erythematosus : clinical, electrophysiological, and laboratory properties and their association with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 46, no. 4 (Oct. / Dec. 2019), pp.285-298.
https://search.emarefa.net/detail/BIM-899744

American Medical Association (AMA)

Imam, Muhammad Hasan& Kuraym, Hamdi Khamis& Hasan, Marwah Muhammad& al-Hadidi, Abir Shawqi& Ibrahim, Nifin Abd Allah. Pattern of peripheral neuropathy in systemic lupus erythematosus : clinical, electrophysiological, and laboratory properties and their association with disease activity. Egyptian Rheumatology and Rehabilitation. 2019. Vol. 46, no. 4, pp.285-298.
https://search.emarefa.net/detail/BIM-899744

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 297-298

Record ID

BIM-899744