Clinical efficacy of intravenous infusion of atropine with micropump in combination with hemoperfusion on organophosphorus poisoning

Joint Authors

Wang, Rui
Liu, Chao
Jiang, Shu Zhi
Ma, Bo-en

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2018-2021, 4 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

4

Main Topic

Diseases
Medicine

Topics

Abstract EN

Objective: To observe the clinical efficacy of intravenous infusion of atropine with micropump in combination with hemoperfusion on organophosphorus poisoning patients, and investigate the potential mechanism.

Methods: In this study, we enrolled 136 organophosphorus poisoning patients who received treatment in this hospital between January 2009 and December 2017, and they were divided into three groups according to the clinical treatment methods, i.e.

Group A (comprehensive treatment with HP, n = 47), Group B (continuous intravenous infusion of atropine with micropump, n = 43) and Group C (regular intravenous infusion of atropine, n = 46).

In addition to the close monitoring of vital signs, we recorded the atropinization time (min), cholinesterase reactivation time (h), total dose of atropine, recurrence, incidence rate of atropine poisoning (%), hospitalization time (d) and cure rate (%).

Results: In comparison with Group C, patients in Group A and B manifested more stable vital signs with lower total dose of atropine and incidence rate of atropine poisoning and shorter cholinesterase reactivation time, while the cure rate was remarkably increased (p < 0.05), and no significant differences were observed in atropinization time among three groups (p > 0.05).

Compared to Group B and C, total dose of atropine in Group A was significantly decreased with obvious excellence in hospitalization time, reduction of complications and increases in cure rates (p < 0.05).

Moreover, patients in Group A had the lowest mortality rate among three groups.

Conclusion: In treatment of organophosphorus poisoning patients, HP and continuous intravenous infusion of atropine using micropump can elevate the survival rate, reduce the incidence of adverse reaction, shorten the reactivation time of cholinesterase and decrease the incidence rate of complications, which are superior to the traditional treatment method.

American Psychological Association (APA)

Jiang, Shu Zhi& Ma, Bo-en& Liu, Chao& Wang, Rui. 2019. Clinical efficacy of intravenous infusion of atropine with micropump in combination with hemoperfusion on organophosphorus poisoning. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2018-2021.
https://search.emarefa.net/detail/BIM-910196

Modern Language Association (MLA)

Jiang, Shu Zhi…[et al.]. Clinical efficacy of intravenous infusion of atropine with micropump in combination with hemoperfusion on organophosphorus poisoning. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2018-2021.
https://search.emarefa.net/detail/BIM-910196

American Medical Association (AMA)

Jiang, Shu Zhi& Ma, Bo-en& Liu, Chao& Wang, Rui. Clinical efficacy of intravenous infusion of atropine with micropump in combination with hemoperfusion on organophosphorus poisoning. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2018-2021.
https://search.emarefa.net/detail/BIM-910196

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2021

Record ID

BIM-910196