Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS

Joint Authors

Li, Genxia
Gao, Wanli
Xu, Yajuan
Xie, Mingkun
Tang, Suhua
Yin, Pan
Guo, Shuhua
Chu, Shuhui
Sultana, Shaima
Cui, Shihong

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2057-2063, 7 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

7

Main Topic

Diseases
Medicine

Topics

Abstract EN

Objective: Through metabolomics method, the objective of the paper is to differentially screen serum metabolites of GDM patients and healthy pregnant women, to explore potential biomarkers of GDM and analyze related pathways, and to explain the potential mechanism and biological significance of GDM.

Methods: The serum samples from 30 GDM patients and 30 healthy pregnant women were selected to conduct non-targeted metabolomics study by liquid chromatography-mass spectrometry.

The differential metabolites between the two groups were searched and the metabolic pathway was analyzed by KEGG database.

Results: Multivariate statistical analysis found that serum metabolism in GDM patients was different significantly from healthy pregnant women, 36 differential metabolites and corresponding metabolic pathways were identified in serum, which involved several metabolic ways like, fatty acid metabolism, butyric acid metabolism, bile secretion, and amino acid metabolism.

Conclusion: The discovery of these biomarkers provided a new theoretical basis and experimental basis for further study of the early diagnosis and pathogenesis of GDM.

At the same time, LC-MS-based serum metabolomics methods also showed great application values in disease diagnosis and mechanism research

American Psychological Association (APA)

Gao, Wanli& Xu, Yajuan& Xie, Mingkun& Tang, Suhua& Yin, Pan& Li, Genxia…[et al.]. 2019. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398

Modern Language Association (MLA)

Li, Genxia…[et al.]. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398

American Medical Association (AMA)

Gao, Wanli& Xu, Yajuan& Xie, Mingkun& Tang, Suhua& Yin, Pan& Li, Genxia…[et al.]. Serum metabonomics study of pregnant women with gestational diabetes mellitus based on LC-MS. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2057-2063.
https://search.emarefa.net/detail/BIM-910398

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2063

Record ID

BIM-910398