Study the markers of follicle stimulating hormone and transforming growth factor β1 in patients with polycystic ovarian syndrome in AL-Najaf Al-Ashraf Province

Abstract EN

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 6-15% of women in age (12-45) years .

It is characterized by disturbance in menstrual cycle ,androgenic features, and presence of multiple small cyst in ovaries in ultrasound.

It is the important cause of infertility.

The etiology of the disease remains unclear and may be associated with insulin resistance, obesity , type 2 diabetes mellitus, hyperandrogenism , environmental and familial genetic factors .

PCOS has a role is the appearance of hirsutism , acne , hypertension and dyslipidemia with increase risk factor of cardiovascular disease (CVD).

Objective : Aim of the study to investigate the pathogenicity, disease severity and early diagnosis roles of follicle stimulating hormone (FSH) and transforming growth factor-beta (TGF-β1) in women with polycystic ovarian syndrome.

Conclusion : Polycystic ovarian syndrome was related to the decrease level of follicle stimulating hormone (FSH) in different age groups where comprised 18.75% in PCOS patients , while increase marker of transforming growth factor β1(TGF- β1) where comprised 46.25% in PCOS patients , these two result cause failure of follicle growth to become mature .