مقارنة نظامين علاجيين لاجتثاث جراثيم الملوية البوابية

Abstract EN

Objective: The importance of Helicobacter pylori (Hp) infection lies in its close relationship with chronic gastritis, peptic ulcer disease and stomach cancer.

This research aims to determine the effectiveness of two regimens in Hp eradication, and its effect on clinical manifestations.

Methods: A prospective study in Aleppo University Hospital consisted of eligible patients who underwent upper gastrointestinal endoscopy with biopsy from the stomach to detect Hp using Giemsa staining.

Hp positive patients received either sequential (group one), or levofloxacin-based triple therapy (group two), with follow-up endoscopy with biopsy after at least one month to detect Hp eradication.

Results: This research was conducted on 70 patients, Hp was positive in 67 patients (95.7%).

The most common indication for endoscopy was abdominal pain (50%).

The most common endoscopic finding in the first group was gastritis (70.8%), and in the second group hiatal hernia (40%).

Patient’s compliance in both groups was 95%.

Side effects occurred in 66.6% and 15% of patients in the first and second group, respectively.

Most patients reported improvement in symptoms post-treatment.

Eradication rate was 0% in the first group, and 10% in the second group.

Conclusions: Although most clinical symptoms have improved in patients who have used sequential or levofloxacinbased triple therapy, but both regimens have failed to eradicate the infection, possibly because of increased bacterial resistance, which requires detailed study of the sensitivity of the antibiotics used in the treatment