The relation between polycystic ovary syndrome and Vitamin D deficiency

Abstract EN

Background: Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS).

Vitamin D deficiency is a common health condition in the reproductive period of women and may escalate the symptoms of PCOS in women.

Objective: The aim of this study was to investigate the association between serum Vitamin D levels in patients with PCOS compared to healthy controls.

Materials and Methods: In the present case–control study, a total of 70 women diagnosed with PCOS were considered cases, and their Vitamin D levels and some other biochemical parameters were compared to 43 apparently healthy controls.

The diagnosis of PCOS was established in line with the Rotterdam Consensus on Diagnostic Criteria for PCOS, including oligo or anovulation, clinical and biochemical signs of hyperandrogenism, and polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen‑secreting tumors, and Cushing’s syndrome).

Results: The study revealed that patients with PCOS were significantly younger compared to the healthy controls; 26.57 versus 33.51; P < 0.001.

Moreover, a higher percentage of patients had irregular menstruation (81.4%) and hirsutism (81.4%) compared to controls (4.7% and 4.7%, P < 0.001, respectively).

The study revealed that the patients had a significantly lower level of Vitamin D and serum prolactin and higher levels thyroid‑stimulating hormone compared to healthy control; 5.49 versus 17.83 ng/ml; 11.94 versus 8.57 IU/L; and 2.50 versus 1.72 IU/L, respectively.

Conclusion: The present study suggests that patients with PCOS were more likely to have irregular menstruation and a lower level of Vitamin D compared to apparently healthy controls.