Inhibition of NF-κB pathway by guggulsterone in the protective effects of cyclophosphamide-induced renal toxicity
Other Title(s)
تثبيط ال NF-KB بواسطة الكوكيلستيرون و التأثير الوقائي للسمية الكلوية للسيكلوفوسفاميد
Joint Authors
Zalzalah, Munaf Hashim
al-Jawdah, Ali Mahmud
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.180-185, 6 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Cyclophosphamide which acts as cytotoxic alkylating agent can induce a renal damage through the toxic metabolites which result from metabolic activation of Cyclophosphamide by cytochrome P-450 inside hepatocyte and develop renal toxicity by direct binding with cellular organelles in the urinary tract cells.
Guggulsterone is a sterol derived from plant has ability to bind to farsenoid X receptor, mineral corticosteroid receptor, androgen receptor, glucocorticoid receptor and estrogen receptor.
It efficiently decreases the pro-inflammatory response by downregulate some of genes that implicate in production and regulation of interleukins (IL-2, IL-4, IL-6 and TNF-α).
In this study, the albino rats were divided to four groups: control group treated with vehicle, cyclophosphamide group, cyclophosphamide with guggulsterone group and guggulsterone alone group.
Guggulsterone doses were administered orally (25 mg/kg/day) for 8 consecutive days while the cyclophosphamide (150 mg/kg) was administered intraperitoneal at day 5 of experiment.
At the end of experiment, the kidney index and the serum level of tumor necrosis factor (TNF-), urea and creatinine were determined, also the NF-κB P65 and catalase tissue activities were measured with histopathological assessment.
The daily dose of guggulsterone produced a significant reduction in the serum level of TNF-a, urea, creatinine, and tissue activities of NF-κB, and catalase enzyme.
The histological feature was also improved.
These data represent the protective effect of guggulsterone against the cyclophosphamide renal toxicity.
American Psychological Association (APA)
al-Jawdah, Ali Mahmud& Zalzalah, Munaf Hashim. 2019. Inhibition of NF-κB pathway by guggulsterone in the protective effects of cyclophosphamide-induced renal toxicity. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.180-185.
https://search.emarefa.net/detail/BIM-947328
Modern Language Association (MLA)
al-Jawdah, Ali Mahmud& Zalzalah, Munaf Hashim. Inhibition of NF-κB pathway by guggulsterone in the protective effects of cyclophosphamide-induced renal toxicity. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.180-185.
https://search.emarefa.net/detail/BIM-947328
American Medical Association (AMA)
al-Jawdah, Ali Mahmud& Zalzalah, Munaf Hashim. Inhibition of NF-κB pathway by guggulsterone in the protective effects of cyclophosphamide-induced renal toxicity. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.180-185.
https://search.emarefa.net/detail/BIM-947328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 184-185
Record ID
BIM-947328