Effect of vitamin E as α-tocopherol acetate on mercuric chlorideinduced chronic oxidoreductive stress and nephrotoxicity in rats
Other Title(s)
تأثير استخدام فيتامين هاء كألفا- توكوفيرول أسيتيت على حالة الجهد التأكسدي الاختزالي الناشئ عن المحدث كلوريد الزئبقيك و المتسبب في حالة التسمم الكلوي في الجرذان
Joint Authors
al-Sumaydi, Ajwad Awwad Muhammad
al-Nuaymi, Nathirah Muhammad Ali
Fadil, Ammar Amir
Source
Iraqi Journal of Veterinary Medicine
Issue
Vol. 43, Issue 2 (31 Dec. 2019), pp.98-108, 11 p.
Publisher
University of Baghdad College of Veterinary Medicine
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Topics
Abstract EN
Impact of vitamin E against mercuric chloride (HgCL2) induced renal toxicity in Wister albino rats was studied.
Feeding of the rats with diet and water contaminated with a non lethal dose of the mercuric chloride (20 parts per million) every other day for 42 days resulted in significant increase of serum malondialdehyde (MDA), which is an important biomarker of the oxidoreductive stress, and significant decline in each of the reduced glutathione (r-GSH) concentration, glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzymes activities, which constitute a vital part of the endogenous protective antioxidant system, as compared to the control group.
The study found that the simultaneous oral co administration of vitamin E (as α-tocopherol acetate) 100 mg/kg B.W.
every other day for 42 days along with mercuric chloride produced a cardinal protective effects against the development of the mercuric chloride induced nephrotoxicity.
This can be through reversing the elevated oxidative stress; induced by the administration of the HgCL2.
In conclusion serum biochemical and kidney histopathological findings of the current study highlight the beneficial effects of vitamin E in rats with HgCl2-mediated renal toxicity.
American Psychological Association (APA)
al-Sumaydi, Ajwad Awwad Muhammad& al-Nuaymi, Nathirah Muhammad Ali& Fadil, Ammar Amir. 2019. Effect of vitamin E as α-tocopherol acetate on mercuric chlorideinduced chronic oxidoreductive stress and nephrotoxicity in rats. Iraqi Journal of Veterinary Medicine،Vol. 43, no. 2, pp.98-108.
https://search.emarefa.net/detail/BIM-952755
Modern Language Association (MLA)
al-Sumaydi, Ajwad Awwad Muhammad…[et al.]. Effect of vitamin E as α-tocopherol acetate on mercuric chlorideinduced chronic oxidoreductive stress and nephrotoxicity in rats. Iraqi Journal of Veterinary Medicine Vol. 43, no. 2 (2019), pp.98-108.
https://search.emarefa.net/detail/BIM-952755
American Medical Association (AMA)
al-Sumaydi, Ajwad Awwad Muhammad& al-Nuaymi, Nathirah Muhammad Ali& Fadil, Ammar Amir. Effect of vitamin E as α-tocopherol acetate on mercuric chlorideinduced chronic oxidoreductive stress and nephrotoxicity in rats. Iraqi Journal of Veterinary Medicine. 2019. Vol. 43, no. 2, pp.98-108.
https://search.emarefa.net/detail/BIM-952755
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 78-81
Record ID
BIM-952755