دراسة المتغيرات الثرمودينامكية لامتزاز دواء هيدروكلوريد البروانولول من محلوله المائي على سطحي الفحم المنشط و قشور البيض المعامل حراريا

Abstract EN

Drug overdose and poisoning are common clinical problems and could occur with propranolol HCl .

This investigation includes the study of adsorption of this drug on activated charcoal and coal of shell eggs which could serve as possible antidotes .

The adsorption was studied at pH= 1 .

The rate and extent of adsorption of the drug on each surface were investigated spectraphotometrically .

The effect of ionic strength has been studied and it was found that the adsorption depends on the concentration of NaCl salt added at (37.5 0 C ) and pH= 1 On Charcoal : 0.1 M > 0.2M > without salt, on coal of shell eggs : 0.2 M > 0.1 M > without salt .

The equilibrium adsorption contact times were determined for both surfaces.

Adsorption isotherms have been analyzed by the Langmuir and Freundlich models.

The Freundlich isotherms have the highest correlation coefficients .

The effect of temperature has been studied on range ( 5 - 42 °C) the apparent thermodynamic parameters (AG , A H , A S) were calculated and the obtained values support that the adsorption on the coal of shell eggs is exothermic while the adsorption on charcoal is endothermic one.