Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis

Other Title(s)

فعالية و سلامة البروبيوتيك و البريبايوتك و السينوبيوتيك في علاج متلازمة القولون المتهيج : مراجعة منهجية و التحليل البعدي

Joint Authors

Asha, Muhammad Zaki
Khalil, Sundus Falih Husni

Source

Sultan Qaboos University Medical Journal

Issue

Vol. 20, Issue 1 (29 Feb. 2020), pp.13-24, 12 p.

Publisher

Sultan Qaboos University College of Medicine and Health Sciences

Publication Date

2020-02-29

Country of Publication

Oman

No. of Pages

12

Main Topic

Diseases

Topics

Abstract EN

Treatments that target alterations in gut microbiota may be beneficial for patients with irritable bowel syndrome (IBS).

A systematic review and meta-analysis was conducted of randomised clinical trials (RCTs) evaluating the efficacy and safety of probiotics, prebiotics and synbiotics.

Factors considered in the analysis included global IBS symptoms and/or abdominal pain, secondary symptoms and the frequency of adverse events.

A total of 33 RCTs involving 4,321 patients were identified.

Overall, probiotics significantly improved global IBS symptoms compared to placebos (standardised mean difference = −0.32, 95% confidence interval: −0.48 to −0.15; P <0.001), with significant heterogeneity between studies (I2 = 72%; P <0.001).

This remained apparent in both single- and multi-strain probiotic interventions as well as synbiotic formulations.

However, evidence regarding prebiotics was scarce.

There were no significant inter-group differences in terms of the frequency of adverse events.

Future RCTs should address methodological limitations, including short follow-up periods and patient adherence.

American Psychological Association (APA)

Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. 2020. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal،Vol. 20, no. 1, pp.13-24.
https://search.emarefa.net/detail/BIM-957295

Modern Language Association (MLA)

Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal Vol. 20, no. 1 (Feb. 2020), pp.13-24.
https://search.emarefa.net/detail/BIM-957295

American Medical Association (AMA)

Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal. 2020. Vol. 20, no. 1, pp.13-24.
https://search.emarefa.net/detail/BIM-957295

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 21-24

Record ID

BIM-957295