Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis
Other Title(s)
فعالية و سلامة البروبيوتيك و البريبايوتك و السينوبيوتيك في علاج متلازمة القولون المتهيج : مراجعة منهجية و التحليل البعدي
Joint Authors
Asha, Muhammad Zaki
Khalil, Sundus Falih Husni
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 20, Issue 1 (29 Feb. 2020), pp.13-24, 12 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2020-02-29
Country of Publication
Oman
No. of Pages
12
Main Subjects
Topics
Abstract EN
Treatments that target alterations in gut microbiota may be beneficial for patients with irritable bowel syndrome (IBS).
A systematic review and meta-analysis was conducted of randomised clinical trials (RCTs) evaluating the efficacy and safety of probiotics, prebiotics and synbiotics.
Factors considered in the analysis included global IBS symptoms and/or abdominal pain, secondary symptoms and the frequency of adverse events.
A total of 33 RCTs involving 4,321 patients were identified.
Overall, probiotics significantly improved global IBS symptoms compared to placebos (standardised mean difference = −0.32, 95% confidence interval: −0.48 to −0.15; P <0.001), with significant heterogeneity between studies (I2 = 72%; P <0.001).
This remained apparent in both single- and multi-strain probiotic interventions as well as synbiotic formulations.
However, evidence regarding prebiotics was scarce.
There were no significant inter-group differences in terms of the frequency of adverse events.
Future RCTs should address methodological limitations, including short follow-up periods and patient adherence.
American Psychological Association (APA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. 2020. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal،Vol. 20, no. 1, pp.13-24.
https://search.emarefa.net/detail/BIM-957295
Modern Language Association (MLA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal Vol. 20, no. 1 (Feb. 2020), pp.13-24.
https://search.emarefa.net/detail/BIM-957295
American Medical Association (AMA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Efficacy and safety of probiotics, prebiotics and synbiotics in the treatment of irritable bowel syndrome : a systematic review and meta-analysis. Sultan Qaboos University Medical Journal. 2020. Vol. 20, no. 1, pp.13-24.
https://search.emarefa.net/detail/BIM-957295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 21-24
Record ID
BIM-957295