Unraveling the mysterious pilocytic astrocytoma : cardinal epidemiological features rummage

Joint Authors

al-Zubi, Muhammad
Khasawinah, Nidal
al-Qrum, Rami
Haddad, Firas
al-Shurbaji, Amir
Malabeh, Qamar
al-Wakfi, Ula
al-Dalahmeh, ala
Basil, Yunus

Source

Journal of the Royal Medical Services

Issue

Vol. 26, Issue 3 (31 Dec. 2019), pp.57-65, 9 p.

Publisher

The Royal Medical Services Jordan Armed Forces

Publication Date

2019-12-31

Country of Publication

Jordan

No. of Pages

9

Main Subjects

Pharmacy, Health & Medical Sciences

Abstract EN

Introduction : Pilocytic astrocytoma is classified as grade I glioma by the (WHO), and although it remains one of the most frequent oncological pathologies located in posterior fossa, it is an intriguing and unpredictable entity.

Pilocytic astrocytomas might be identified supratentorially or in the optic pathway.

The close vicinity of these lesions to the brainstem and fourth ventricle zone explains the hazardous presentation of these patients.

Large multi-institutional reports illustrating the epidemiology of pilocytic astrocytoma surgery especially in developing countries are lacking.

Objectives : The current research is supplementary to other published works, and it aimed to use a retrospectively collected data registry of surgically treated patients to primarily delineate the relative frequencies of pilocytic astrocytomas.

Special emphasis was devoted to analyzing the cardinal epidemiological features and major concurrent issues.

Methods and Patients : This retrospective review data in the Institutional patient database for all patients who underwent surgical intervention in the Department of Neurosurgery at a single referral center – King Hussein Medical Center-over an 18-year period from January 2000 to December 2018 were scrutinized.

Clinical records, as well as computed tomography and magnetic resonance imaging (MRI) reports, surgical notes, follow up records , and histopathological reports were obtained from all indexing systems that are used, and the data were analyzed for all patients.

Patients within the age range of 1 to 37 years were included in the study.

Results : There were 102-patients in this study; 53 were females and 49 were males (male-to-female ratio of 1:1.1).

The mean age was 12.01 years.

Topographically, the posterior fossa was the most common region where pilocytic astrocytomas are found, followed by 13 in the supra-sellar region.

The most common clinical presentation of pilocytic astrocytoma was a marked increased intracranial pressure.

There was cranial nerves involvement in 2.94 % of cases.

Symptomatic hydrocephalus was evident in 39-patients as the primary presentation.

Endocrinological disturbances were manifested in seven Patients.

Visual difficulties were identified in six patients.

Nine patients showed lesion recurrence and underwent a second surgery and one patient showed a second recurrence with transformation to a grade III tumor.

The general complication rate in our study was 21.56 %.

Overall, no mortality was correlated to pilocytic astrocytoma.

Conclusions : Pilocytic astrocytoma data from our analysis revealed: a slight female predominance and younger age and presentation in our patients in addition to an insidious clinical demonstration with marked increased intracranial pressure.

The largest proportion of pilocytic astocytomas located in the posterior fossa.

Treatment options have improved the survival rate, and recurrence rates are very low because of a feasible gross total excision.

American Psychological Association (APA)

al-Qrum, Rami& Malabeh, Qamar& al-Wakfi, Ula& al-Zubi, Muhammad& al-Dalahmeh, ala& Haddad, Firas…[et al.]. 2019. Unraveling the mysterious pilocytic astrocytoma : cardinal epidemiological features rummage. Journal of the Royal Medical Services،Vol. 26, no. 3, pp.57-65.
https://search.emarefa.net/detail/BIM-957840

Modern Language Association (MLA)

al-Qrum, Rami…[et al.]. Unraveling the mysterious pilocytic astrocytoma : cardinal epidemiological features rummage. Journal of the Royal Medical Services Vol. 26, no. 3 (Dec. 2019), pp.57-65.
https://search.emarefa.net/detail/BIM-957840

American Medical Association (AMA)

al-Qrum, Rami& Malabeh, Qamar& al-Wakfi, Ula& al-Zubi, Muhammad& al-Dalahmeh, ala& Haddad, Firas…[et al.]. Unraveling the mysterious pilocytic astrocytoma : cardinal epidemiological features rummage. Journal of the Royal Medical Services. 2019. Vol. 26, no. 3, pp.57-65.
https://search.emarefa.net/detail/BIM-957840

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 64-65

Record ID

BIM-957840