Huntington disease with psychiatric presentation

Abstract EN

Huntington disease (HD) is a neurodegenerative disease.

It is inherited as an autosomal-dominant disease characterized by a triad of progressive motor decline, deteriorating cognitive function, and a broad spectrum of psychiatric symptoms.

We report a case of a severe form of HD with significant cognitive impairment and psychosis that was fairly controlled with antipsychotics (Haloperidol and Olanzapine), anti-dementia medications (Memantine), and anti-chorea treatment (Tetrabenazine).

The patient had three stages: pre-symptomatic, prodromal, and manifest.

Early detection of HD will significantly improve the medical and mental condition; the current recommendation is not to screen those who are below 18 years of age.