An infant with a severe combined immunodeficiency caused by zeta chain-associated protein 70 (ZAP-70)‎ deficiency

Joint Authors

Ali, Maryam Fuad
Isa, Abd Allah Ali
Isa, Hasan M.
al-Shaykh, Muhammad

Source

Bahrain Medical Bulletin

Issue

Vol. 42, Issue 1 (31 Mar. 2020), pp.61-63, 3 p.

Publisher

King Hamad University Hospital

Publication Date

2020-03-31

Country of Publication

Bahrain

No. of Pages

3

Main Topic

Diseases

Topics

Abstract EN

Zeta Chain-Associated Protein Kinase 70 (ZAP-70) is a protein kinase involved in the T-cell receptor (TCR) signaling; therefore, it plays a significant role in T-cell functioning.

ZAP-70 related severe combined immune deficiency (SCID) is a rare autosomal recessive disorder.

Various clinical presentations of the condition were described in the literature; it was suggested that this clinical heterogeneity may delay the diagnosis.

A ten-month-old infant presented with fever and cough.

He was admitted to the PICU.

Investigations revealed a tracheal aspirate positive for candida.

This case is the first case of ZAP- 70 related SCID to be reported in Bahrain.

American Psychological Association (APA)

al-Shaykh, Muhammad& Isa, Abd Allah Ali& Ali, Maryam Fuad& Isa, Hasan M.. 2020. An infant with a severe combined immunodeficiency caused by zeta chain-associated protein 70 (ZAP-70) deficiency. Bahrain Medical Bulletin،Vol. 42, no. 1, pp.61-63.
https://search.emarefa.net/detail/BIM-958180

Modern Language Association (MLA)

al-Shaykh, Muhammad…[et al.]. An infant with a severe combined immunodeficiency caused by zeta chain-associated protein 70 (ZAP-70) deficiency. Bahrain Medical Bulletin Vol. 42, no. 1 (Mar. 2020), pp.61-63.
https://search.emarefa.net/detail/BIM-958180

American Medical Association (AMA)

al-Shaykh, Muhammad& Isa, Abd Allah Ali& Ali, Maryam Fuad& Isa, Hasan M.. An infant with a severe combined immunodeficiency caused by zeta chain-associated protein 70 (ZAP-70) deficiency. Bahrain Medical Bulletin. 2020. Vol. 42, no. 1, pp.61-63.
https://search.emarefa.net/detail/BIM-958180

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 63

Record ID

BIM-958180