Pharmacological approaches to diabetic gastroparesis : a systematic review of randomised clinical trials
Other Title(s)
النهج الدوائية لعلاج خزل المعدة السكري : مراجعة منهجية للتجارب السريرية العشوائية
Joint Authors
Asha, Muhammad Zaki
Khalil, Sundus Falih Husni
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 19, Issue 4 (30 Nov. 2019), pp.291-304, 14 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2019-11-30
Country of Publication
Oman
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Pharmacological interventions of diabetic gastroparesis (DG) constitute an essential element of a patient’s management.
This article aimed to systematically review the available pharmacological approaches of DG, including their efficacy and safety.
A total of 24 randomised clinical trials (RCTs) that investigated the efficacy and/or safety of medications targeting DG symptoms were identified using several online databases.
Their results revealed that metoclopramide was the only approved drug for accelerating gastric emptying and improving disease symptoms.
However, this medication may have several adverse effects on the cardiovascular and nervous systems, which might be resolved with a new intranasal preparation.
Acceptable alternatives are oral domperidone for patients without cardiovascular risk factors or intravenous erythromycin for hospitalised patients.
Preliminary data indicated that relamorelin and prucalopride are novel candidates that have proven to be effective and safe.
Future RCTs should be conducted based on unified guidelines using universal diagnostic modalities to reveal reliable and comprehensive outcomes.
American Psychological Association (APA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. 2019. Pharmacological approaches to diabetic gastroparesis : a systematic review of randomised clinical trials. Sultan Qaboos University Medical Journal،Vol. 19, no. 4, pp.291-304.
https://search.emarefa.net/detail/BIM-960178
Modern Language Association (MLA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Pharmacological approaches to diabetic gastroparesis : a systematic review of randomised clinical trials. Sultan Qaboos University Medical Journal Vol. 19, no. 4 (Nov. 2019), pp.291-304.
https://search.emarefa.net/detail/BIM-960178
American Medical Association (AMA)
Asha, Muhammad Zaki& Khalil, Sundus Falih Husni. Pharmacological approaches to diabetic gastroparesis : a systematic review of randomised clinical trials. Sultan Qaboos University Medical Journal. 2019. Vol. 19, no. 4, pp.291-304.
https://search.emarefa.net/detail/BIM-960178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 301-304
Record ID
BIM-960178