The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy

Other Title(s)

أهمية ظهور ربيطة الموت المبرمج 1 في مرضى السرطان الذين تلقوا المعالجة الكيميائية المسبقة

Joint Authors

Salih, Jumanah
al-Dughaishi, Malikah
Shalabi, Asim
al-Rabkhiah, Khawlah
Bu Daghah, Ammar
Bu lassil, Muhammad Rashid

Source

Sultan Qaboos University Medical Journal

Issue

Vol. 19, Issue 4 (30 Nov. 2019), pp.277-283, 7 p.

Publisher

Sultan Qaboos University College of Medicine and Health Sciences

Publication Date

2019-11-30

Country of Publication

Oman

No. of Pages

7

Main Subjects

Pharmacy, Health & Medical Sciences

Abstract EN

Programmed death ligand 1 (PD-L1) is an inhibitory molecule expressed by cancer cells to supress T-cell activity and escape anti-tumour immunity.

The role of PD-L1 in cancer has been studied extensively as it is considered an important immune checkpoint against immune over-activation through its interaction with Programmed death receptor 1 (PD-1) expressed on activated lymphocytes.

PD-L1 expression was found to be enhanced by chemotherapy through different proliferation pathways.

However, the predictive and prognostic value for PD-L1 expression in cancer patients treated with neoadjuvant chemotherapy (NAC) is not yet established.

This review focused on the potential effects of chemotherapy on PD-L1 expression and the role of PD-L1 as a prognostic and predictive marker in NAC-treated cancer patients.

In addition, the potential use of this marker in clinical practice is discussed.

American Psychological Association (APA)

al-Dughaishi, Malikah& Shalabi, Asim& al-Rabkhiah, Khawlah& Bu Daghah, Ammar& Bu lassil, Muhammad Rashid& Salih, Jumanah. 2019. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal،Vol. 19, no. 4, pp.277-283.
https://search.emarefa.net/detail/BIM-960180

Modern Language Association (MLA)

al-Dughaishi, Malikah…[et al.]. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal Vol. 19, no. 4 (Nov. 2019), pp.277-283.
https://search.emarefa.net/detail/BIM-960180

American Medical Association (AMA)

al-Dughaishi, Malikah& Shalabi, Asim& al-Rabkhiah, Khawlah& Bu Daghah, Ammar& Bu lassil, Muhammad Rashid& Salih, Jumanah. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal. 2019. Vol. 19, no. 4, pp.277-283.
https://search.emarefa.net/detail/BIM-960180

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 282-283

Record ID

BIM-960180