The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy
Other Title(s)
أهمية ظهور ربيطة الموت المبرمج 1 في مرضى السرطان الذين تلقوا المعالجة الكيميائية المسبقة
Joint Authors
Salih, Jumanah
al-Dughaishi, Malikah
Shalabi, Asim
al-Rabkhiah, Khawlah
Bu Daghah, Ammar
Bu lassil, Muhammad Rashid
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 19, Issue 4 (30 Nov. 2019), pp.277-283, 7 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2019-11-30
Country of Publication
Oman
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Programmed death ligand 1 (PD-L1) is an inhibitory molecule expressed by cancer cells to supress T-cell activity and escape anti-tumour immunity.
The role of PD-L1 in cancer has been studied extensively as it is considered an important immune checkpoint against immune over-activation through its interaction with Programmed death receptor 1 (PD-1) expressed on activated lymphocytes.
PD-L1 expression was found to be enhanced by chemotherapy through different proliferation pathways.
However, the predictive and prognostic value for PD-L1 expression in cancer patients treated with neoadjuvant chemotherapy (NAC) is not yet established.
This review focused on the potential effects of chemotherapy on PD-L1 expression and the role of PD-L1 as a prognostic and predictive marker in NAC-treated cancer patients.
In addition, the potential use of this marker in clinical practice is discussed.
American Psychological Association (APA)
al-Dughaishi, Malikah& Shalabi, Asim& al-Rabkhiah, Khawlah& Bu Daghah, Ammar& Bu lassil, Muhammad Rashid& Salih, Jumanah. 2019. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal،Vol. 19, no. 4, pp.277-283.
https://search.emarefa.net/detail/BIM-960180
Modern Language Association (MLA)
al-Dughaishi, Malikah…[et al.]. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal Vol. 19, no. 4 (Nov. 2019), pp.277-283.
https://search.emarefa.net/detail/BIM-960180
American Medical Association (AMA)
al-Dughaishi, Malikah& Shalabi, Asim& al-Rabkhiah, Khawlah& Bu Daghah, Ammar& Bu lassil, Muhammad Rashid& Salih, Jumanah. The value of programmed death ligand 1 expression in cancer patients treated with neoadjuvant chemotherapy. Sultan Qaboos University Medical Journal. 2019. Vol. 19, no. 4, pp.277-283.
https://search.emarefa.net/detail/BIM-960180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 282-283
Record ID
BIM-960180