Methylene tetrahydrofolate reductase gene polymorphism C677T and risk of type two diabetes mellitus in Beni-Suef Governorate

Joint Authors

Tawfiq, M. S.
Dimlawi, Hibah Hamdi
Farhan, Hanan Muhammad
al-Isawi, Dina F.

Source

Arab Journal of Nuclear Sciences and Applications

Issue

Vol. 53, Issue 2 (30 Apr. 2020), pp.159-166, 8 p.

Publisher

The Egyptian Society of Nuclear Science and Applications

Publication Date

2020-04-30

Country of Publication

Egypt

No. of Pages

8

Main Topic

Diseases

Topics

Abstract EN

: Methylene Tetrahydrofolate Reductase (MTHFR) is known to be a regulatory enzyme of homocysteine metabolism.

In many ethnic groups point mutations in MTHFR gene are implicated in the pathogenesis of diabetic nephropathy (DN) and other complications of type II diabetes mellitus (T2DM).

Aim of the work: The aim of this study was to assess if MTHFR C677T gene polymorphism was one of the risk factors for the development of diabetic nephropathy as well as other complications in type 2 diabetes mellitus patients.

Subjects and methods: The MTHFR C6777T polymorphisms were detected in 50 persons by PCR-RFLP.

Subjects were divided into 2 groups; 30 patients with type II DM and 20 persons who were non-diabetic healthy controls.

Results: The presence of MTHFR 677T allele did not increase the risk of complications in T2DM patients.

The presence of mutant genotypes CT and TT did not increase the risk of nephropathy or other complications in the subjects having a C677T mutation.

Conclusion: Methylene Tetrahydrofolate Reductase (MTHFR) C677T gene mutation was neither associated with an increased risk of diabetic nephropathy nor other complications of type II diabetes mellitus.

American Psychological Association (APA)

Dimlawi, Hibah Hamdi& Farhan, Hanan Muhammad& al-Isawi, Dina F.& Tawfiq, M. S.. 2020. Methylene tetrahydrofolate reductase gene polymorphism C677T and risk of type two diabetes mellitus in Beni-Suef Governorate. Arab Journal of Nuclear Sciences and Applications،Vol. 53, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-980041

Modern Language Association (MLA)

Dimlawi, Hibah Hamdi…[et al.]. Methylene tetrahydrofolate reductase gene polymorphism C677T and risk of type two diabetes mellitus in Beni-Suef Governorate. Arab Journal of Nuclear Sciences and Applications Vol. 53, no. 2 (2020), pp.159-166.
https://search.emarefa.net/detail/BIM-980041

American Medical Association (AMA)

Dimlawi, Hibah Hamdi& Farhan, Hanan Muhammad& al-Isawi, Dina F.& Tawfiq, M. S.. Methylene tetrahydrofolate reductase gene polymorphism C677T and risk of type two diabetes mellitus in Beni-Suef Governorate. Arab Journal of Nuclear Sciences and Applications. 2020. Vol. 53, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-980041

Data Type

Journal Articles

Language

English

Notes

-

Record ID

BIM-980041