Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study

Joint Authors

Atey, Tesfay Mehari
Bitew, Helen
Asgedom, Solomon Weldegebreal
Endrias, Asrat
Berhe, Derbew Fikadu

Source

AIDS Research and Treatment

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-01-21

Country of Publication

Egypt

No. of Pages

11

Main Topic

Diseases
Medicine

Abstract EN

|Objectives.

Early antiretroviral therapy (ART), isoniazid preventive therapy (IPT), and isoniazid-rifapentine (3HP) are effective strategies for preventing tuberculosis (TB) among people living with HIV (PLHIV).

The study aimed to determine the effect of IPT on the TB incidence, follow-up CD4+ T cells, and all-cause mortality rate.

Participants.

Eligible patients on ART (n = 1, 863) were categorized into one-to-two ratios of exposed groups to IPT (n = 621) and nonexposed groups to IPT (n = 1, 242).

Exposed groups entered the cohort at their first prescription of IPT, and unexposed groups entered into the study at the first prescription of ART and then followed until the occurrence of the outcome or date of administrative censoring (June 30, 2017).

The outcome endpoints were TB incidence, follow-up CD4+ T cells, and all-cause mortality rate.

Results.

The follow-up CD4+ T cells for the exposed and nonexposed groups were 405.74 and 366.95 cells/mm (World Health Organization (WHO), 2017), respectively, a statistically significant finding (t1861 = −3.770, p<0.0001; Cohen’s d = 0.186).

Nine percent of the exposed patients (620 incidence of TB per 100,000 person-years (PYs)) and 21.9% of the nonexposed patients (3160 incidence of TB per 100,000 PYs) developed TB.

Mortality rate (per 100,000 PYs) was 440 for the exposed and 1490 for the unexposed patients.

Statistically significant determinants of the all-cause mortality were unscheduled follow-up (AHR = 1.601; 95% CI: 1.154–2.222) and unable to work properly (AHR = 2.324; 95% CI: 1.643–3.288).

Conclusion.

This study demonstrates the effect of IPT in reducing incidence of TB and all-cause mortality rate and improving follow-up CD4+ T cells.

Promoting IPT use can help to achieve the TB eradicating national agenda in Ethiopia.

American Psychological Association (APA)

Atey, Tesfay Mehari& Bitew, Helen& Asgedom, Solomon Weldegebreal& Endrias, Asrat& Berhe, Derbew Fikadu. 2020. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-986233

Modern Language Association (MLA)

Atey, Tesfay Mehari…[et al.]. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-986233

American Medical Association (AMA)

Atey, Tesfay Mehari& Bitew, Helen& Asgedom, Solomon Weldegebreal& Endrias, Asrat& Berhe, Derbew Fikadu. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-986233

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-986233