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Do the Changes in the Serum Levels of IL-2, IL-4, TNFα, and IL-6 Reflect the Inflammatory Activity in the Patients with Post-ERCP Pancreatitis?
Joint Authors
Bagci, Sait
Uygun, Ahmet
Tuzun, Ahmet
Oktenli, Cagatay
Oren, Sema
Kilciler, Guldem
Gulsen, Mustafa
Yesilova, Zeki
Musabak, Ugur
Karaeren, Necmettin
Source
Journal of Immunology Research
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Acute pancreatitis is the major complication of endoscopic retrograde cholangiopancreatography (ERCP) procedure and there are some reports showing cytokine changes in ERCP-induced pancreatits.
Goals.
To investigate the association between early changes (within 24 hours) in the serum interleukin (IL)-2, IL-4, tumor necrosis factor (TNF)α, and IL-6 levels and the development of post-ERCP pancreatitis.
Study.
Forty five consecutive patients who underwent therapeutic ERCP and 10 patients with acute pancreatitis without ERCP were enrolled to the study.
Serum concentrations of IL-2, IL-4, TNFα, and IL-6 were determined immediately before, 12 hours and 24 hours after ERCP.
Results.
Seven of the 45 patients (15.5%) developed post-ERCP pancreatitis.
The levels of IL-4 at 24 hours after ERCP were significantly lower in the patients with post-ERCP pancreatitis than in those without pancreatitis, while TNFα levels at 12 hours after ERCP were higher in the complicated group than those of the uncomplicated group.
The ratios of TNFα/IL-4 at 12 and 24 hours after ERCP were found significantly higher in the patients with post-ERCP pancreatitis than in those without pancreatitis.
IL-6 in the complicated patients was found significantly increased at 24 hours after ERCP.
Conclusions.
The enhancement of serum TNFα and IL-6 levels in the patients with ERCP-induced pancreatitis reflects the inflammatory activity.
Additionally, these cytokines together with IL-4 can be used in clinical laboratory monitoring of ERCP.
American Psychological Association (APA)
Kilciler, Guldem& Musabak, Ugur& Bagci, Sait& Yesilova, Zeki& Tuzun, Ahmet& Uygun, Ahmet…[et al.]. 2008. Do the Changes in the Serum Levels of IL-2, IL-4, TNFα, and IL-6 Reflect the Inflammatory Activity in the Patients with Post-ERCP Pancreatitis?. Journal of Immunology Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988065
Modern Language Association (MLA)
Kilciler, Guldem…[et al.]. Do the Changes in the Serum Levels of IL-2, IL-4, TNFα, and IL-6 Reflect the Inflammatory Activity in the Patients with Post-ERCP Pancreatitis?. Journal of Immunology Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-988065
American Medical Association (AMA)
Kilciler, Guldem& Musabak, Ugur& Bagci, Sait& Yesilova, Zeki& Tuzun, Ahmet& Uygun, Ahmet…[et al.]. Do the Changes in the Serum Levels of IL-2, IL-4, TNFα, and IL-6 Reflect the Inflammatory Activity in the Patients with Post-ERCP Pancreatitis?. Journal of Immunology Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-988065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988065