Early Expression of FcγRI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients
Joint Authors
Mandak, Jiri
Kolackova, Martina
Jankovicova, Karolina
Krejsek, Jan
Kunes, Pavel
Lonsky, Vladimir
Andrys, Ctirad
Kudlova, Manuela
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-01-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Activation of innate immunity cells is inseparably linked to cardiac surgical operation.
The aim of this study was to assess the kinetics in the expression of receptor for Fc part of IgG, FcγRI (CD64), and scavenger receptor CD163 on peripheral blood cells of cardiac surgical patients and to examine the effect of cardiac bypass as a separable influence on the systemic acute inflammatory response.
Methods.
Forty patients, twenty in each group, were randomly assigned to CABG surgery performed either with “on-pump” or without “off-pump” cardiopulmonary bypass.
Standardized quantitative flow cytometry method was used to determine the expression of surface markers.
Results.
The density of CD64 molecule on monocytes reached maximum on the 1st postoperative day (P<.001) whereas the peak for CD64 molecule expression on granulocytes was postponed to the 3rd postoperative day (P<.001).
The expression of CD163 scavenger molecule on monocytes reached maximum on the 1st postoperative day (P<.001).
The density of CD163 molecule on monocytes on the 1st postoperative day is significantly higher in “on-pump” patients in comparison with “off-pump” patients (P<.001).
Conclusion.
In cardiac surgical patients the expression of activation marker FcγR1 (CD64) on monocytes is increased earlier in comparison with granulocytes in both “on-pump” and “off-pump” patients.
The expression of scavenger molecule CD163 on monocytes is significantly higher in “on-pump” patients.
American Psychological Association (APA)
Kolackova, Martina& Kudlova, Manuela& Kunes, Pavel& Lonsky, Vladimir& Mandak, Jiri& Andrys, Ctirad…[et al.]. 2008. Early Expression of FcγRI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988141
Modern Language Association (MLA)
Kolackova, Martina…[et al.]. Early Expression of FcγRI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988141
American Medical Association (AMA)
Kolackova, Martina& Kudlova, Manuela& Kunes, Pavel& Lonsky, Vladimir& Mandak, Jiri& Andrys, Ctirad…[et al.]. Early Expression of FcγRI (CD64) on Monocytes of Cardiac Surgical Patients and Higher Density of Monocyte Anti-Inflammatory Scavenger CD163 Receptor in “On-Pump” Patients. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988141