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Lymphotoxin-α Plays Only a Minor Role in Host Resistance to Respiratory Infection with Virulent Type A Francisella tularensis in Mice
Joint Authors
Chen, Wangxue
KuoLee, Rhonda
Zhang, Deng
Conlan, J. Wayne
Harris, Greg
Zhang, Qinxian
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study examined the role of lymphotoxin (LT)-α in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia.
Following a low-dose aerosol infection with the highly virulent type A strain of F.
tularensis, mice deficient in LTα (LTα−/−) consistently harbored approximately 10-fold fewer bacteria in their spleens at day 2 and 10-fold more bacteria in their lungs at day 4 than LTα+/+ mice.
However, the mortality and median time to death were indistinguishable between the two mouse strains.
In addition, the inflammatory responses to the infection, as reflected by the cytokine levels and leukocyte influx in the bronchoalveolar lavage fluid and histopathological analysis, were generally similar between LTα−/− and LTα+/+ mice.
These data suggest that although LTα does not contribute significantly to the resistance and host responses of mice to airborne type A F.
tularensis infection, it does play a subtle role in the multiplication/dissemination of F.
tularensis.
American Psychological Association (APA)
Zhang, Deng& KuoLee, Rhonda& Harris, Greg& Zhang, Qinxian& Conlan, J. Wayne& Chen, Wangxue. 2008. Lymphotoxin-α Plays Only a Minor Role in Host Resistance to Respiratory Infection with Virulent Type A Francisella tularensis in Mice. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988142
Modern Language Association (MLA)
KuoLee, Rhonda…[et al.]. Lymphotoxin-α Plays Only a Minor Role in Host Resistance to Respiratory Infection with Virulent Type A Francisella tularensis in Mice. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988142
American Medical Association (AMA)
Zhang, Deng& KuoLee, Rhonda& Harris, Greg& Zhang, Qinxian& Conlan, J. Wayne& Chen, Wangxue. Lymphotoxin-α Plays Only a Minor Role in Host Resistance to Respiratory Infection with Virulent Type A Francisella tularensis in Mice. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988142