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PPARγ and MEK Interactions in Cancer
Joint Authors
Seger, Rony
Burgermeister, Elke
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-gamma (PPARγ) exerts multiple functions in determination of cell fate, tissue metabolism, and host immunity.
Two synthetic PPARγ ligands (rosiglitazone and pioglitazone) were approved for the therapy of type-2 diabetes mellitus and are expected to serve as novel cures for inflammatory diseases and cancer.
However, PPARγ and its ligands exhibit a janus-face behaviour as tumor modulators in various systems, resulting in either tumor suppression or tumor promotion.
This may be in part due to signaling crosstalk to the mitogen-activated protein kinase (MAPK) cascades.
The genomic activity of PPARγ is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2).
PPARγ ligands themselves activate the ERK cascade through nongenomic and often PPARγ-independent signaling.
In the current review, we discuss the molecular mechanisms and physiological implications of the crosstalk of PPARγ with MEK-ERK signaling and its potential as a novel drug target for cancer therapy in patients.
American Psychological Association (APA)
Burgermeister, Elke& Seger, Rony. 2008. PPARγ and MEK Interactions in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-16.
https://search.emarefa.net/detail/BIM-988193
Modern Language Association (MLA)
Burgermeister, Elke& Seger, Rony. PPARγ and MEK Interactions in Cancer. PPAR Research No. 2008 (2008), pp.1-16.
https://search.emarefa.net/detail/BIM-988193
American Medical Association (AMA)
Burgermeister, Elke& Seger, Rony. PPARγ and MEK Interactions in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-16.
https://search.emarefa.net/detail/BIM-988193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988193