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The PPAR-γ Agonist 15-Deoxy-Δ12,14-Prostaglandin J2 Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease
Joint Authors
Drew, Paul D.
Barger, Steven W.
Xu, Jihong
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Accumulation of amyloid-β peptide (Aβ) appears to contribute to the pathogenesis of Alzheimer's disease (AD).
Therapeutic hope for the prevention or removal of Aβ deposits has been placed in strategies involving immunization against the Aβ peptide.
Initial Aβ immunization studies in animal models of AD showed great promise.
However, when this strategy was attempted in human subjects with AD, an unacceptable degree of meningoencephalitis occurred.
It is generally believed that this adverse outcome resulted from a T-cell response to Aβ.
Specifically, CD4+ Th1 and Th17 cells may contribute to severe CNS inflammation and limit the utility of Aβ immunization in the treatment of AD.
Interleukin (IL)-12 and IL-23 play critical roles in the development of Th1 and Th17 cells, respectively.
In the present study, Aβ1−42 synergistically elevated the expression of IL-12 and IL-23 triggered by inflammatory activation of microglia, and the peroxisome proliferator-activated receptor (PPAR)-γ agonist 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2) effectively blocked the elevation of these proinflammatory cytokines.
Furthermore, 15d-PGJ2 suppressed the Aβ-related synergistic induction of CD14, MyD88, and Toll-like receptor 2, molecules that play critical roles in neuroinflammatory conditions.
Collectively, these studies suggest that PPAR-γ agonists may be effective in modulating the development of AD.
American Psychological Association (APA)
Xu, Jihong& Barger, Steven W.& Drew, Paul D.. 2008. The PPAR-γ Agonist 15-Deoxy-Δ12,14-Prostaglandin J2 Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988198
Modern Language Association (MLA)
Xu, Jihong…[et al.]. The PPAR-γ Agonist 15-Deoxy-Δ12,14-Prostaglandin J2 Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-988198
American Medical Association (AMA)
Xu, Jihong& Barger, Steven W.& Drew, Paul D.. The PPAR-γ Agonist 15-Deoxy-Δ12,14-Prostaglandin J2 Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988198