A Role for PPARβδ in Tumor Stroma and Tumorigenesis
Joint Authors
Müller-Brüsselbach, Sabine
Müller, Rolf
Peters, Jeffrey M.
Kömhoff, Martin
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a transcription factor that is activated by endogenous fatty acid ligands and by synthetic agonists.
Its role in the regulation of skeletal muscle fatty acid catabolism, glucose homeostasis, and cellular differentiation has been established in multiple studies.
On the contrary, a role for PPARβ/δ in tumorigenesis is less clear because there are contradictory reports in the literature.
However, the majority of these studies have not examined the role of PPARβ/δ in the tumor stroma.
Recent evidence suggests that stromal PPARβ/δ regulates tumor endothelial cell proliferation and promotes differentiation leading to the properly orchestrated events required for tumor blood vessel formation.
This review briefly summarizes the significance of these studies that may provide clues to help explain the reported discrepancies in the literature regarding the role of PPARβ/δ in tumorigenesis.
American Psychological Association (APA)
Müller, Rolf& Kömhoff, Martin& Peters, Jeffrey M.& Müller-Brüsselbach, Sabine. 2008. A Role for PPARβδ in Tumor Stroma and Tumorigenesis. PPAR Research،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988214
Modern Language Association (MLA)
Müller, Rolf…[et al.]. A Role for PPARβδ in Tumor Stroma and Tumorigenesis. PPAR Research No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-988214
American Medical Association (AMA)
Müller, Rolf& Kömhoff, Martin& Peters, Jeffrey M.& Müller-Brüsselbach, Sabine. A Role for PPARβδ in Tumor Stroma and Tumorigenesis. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-988214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988214