PPARγ and Apoptosis in Cancer
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) are ligand binding transcription factors which function in many physiological roles including lipid metabolism, cell growth, differentiation, and apoptosis.
PPARs and their ligands have been shown to play a role in cancer.
In particular, PPARγ ligands including endogenous prostaglandins and the synthetic thiazolidinediones (TZDs) can induce apoptosis of cancer cells with antitumor activity.
Thus, PPARγ ligands have a potential in both chemoprevention and therapy of several types of cancer either as single agents or in combination with other antitumor agents.
Accordingly, the involvement of PPARγ and its ligands in regulation of apoptosis of cancer cells have been extensively studied.
Depending on cell types or ligands, induction of apoptosis in cancer cells by PPARγ ligands can be either PPARγ-dependent or -independent.
Through increasing our understanding of the mechanisms of PPARγ ligand-induced apoptosis, we can develop better strategies which may include combining other antitumor agents for PPARγ-targeted cancer chemoprevention and therapy.
This review will highlight recent research advances on PPARγ and apoptosis in cancer.
American Psychological Association (APA)
Elrod, Heath A.& Sun, Shi-Yong. 2008. PPARγ and Apoptosis in Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988231
Modern Language Association (MLA)
Elrod, Heath A.& Sun, Shi-Yong. PPARγ and Apoptosis in Cancer. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988231
American Medical Association (AMA)
Elrod, Heath A.& Sun, Shi-Yong. PPARγ and Apoptosis in Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988231