A Novel Mechanism of PPARγ Regulation of TGFβ1: Implication in Cancer Biology
Joint Authors
Kim, Hyung Don
Shin, Sang Mi
Kim, Sang Geon
Lee, Chang Ho
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPARγ) and retinoic acid X-receptor (RXR) heterodimer, which regulates cell growth and differentiation, represses the TGFβ1 gene that encodes for the protein involved in cancer biology.
This review will introduce the novel mechanism associated with the inhibition of the TGFβ1 gene by PPARγ activation, which regulates the dephosphorylation of Zf9 transcription factor.
Pharmacological manipulation of TGFβ1 by PPARγ activators can be applied for treating TGFβ1-induced pathophysiologic disorders such as cancer metastasis and fibrosis.
In this article, we will discuss the opposing effects of TGFβ on tumor growth and metastasis, and address the signaling pathways regulated by PPARγ for tumor progression and suppression.
American Psychological Association (APA)
Lee, Chang Ho& Kim, Hyung Don& Shin, Sang Mi& Kim, Sang Geon. 2008. A Novel Mechanism of PPARγ Regulation of TGFβ1: Implication in Cancer Biology. PPAR Research،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988237
Modern Language Association (MLA)
Lee, Chang Ho…[et al.]. A Novel Mechanism of PPARγ Regulation of TGFβ1: Implication in Cancer Biology. PPAR Research No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-988237
American Medical Association (AMA)
Lee, Chang Ho& Kim, Hyung Don& Shin, Sang Mi& Kim, Sang Geon. A Novel Mechanism of PPARγ Regulation of TGFβ1: Implication in Cancer Biology. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-988237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988237
