PPARγ Inhibitors as Novel Tubulin-Targeting Agents
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The microtubule-targeting agents (MTAs) are a very successful class of cancer drugs with therapeutic benefits in both hematopoietic and solid tumors.
However, resistance to these drugs is a significant problem.
Current MTAs bind to microtubules, and/or to their constituent tubulin heterodimers, and affect microtubule polymerization and dynamics.
The PPARγ inhibitor T0070907 can reduce tubulin levels in colorectal cancer cell lines and suppress tumor growth in a murine xenograft model.
T0070907 does not alter microtubule polymerization in vitro, and does not appear to work by triggering modulation of tubulin RNA levels subsequent to decreased polymerization.
This observation suggests the possible development of antimicrotubule drugs that work by a novel mechanism, and implies the presence of cancer therapeutic targets that have not yet been exploited.
This review summarizes what is known about PPARγ inhibitors and cancer cell death, with emphasis on the tubulin phenotype and PPAR-dependence, and identifies potential mechanisms of action.
American Psychological Association (APA)
Schaefer, Katherine L.. 2008. PPARγ Inhibitors as Novel Tubulin-Targeting Agents. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988238
Modern Language Association (MLA)
Schaefer, Katherine L.. PPARγ Inhibitors as Novel Tubulin-Targeting Agents. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-988238
American Medical Association (AMA)
Schaefer, Katherine L.. PPARγ Inhibitors as Novel Tubulin-Targeting Agents. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-988238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988238