A Role for PPARβδ in Ocular Angiogenesis
Author
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The uses of highly selective PPARβ/δ ligands and PPARβ/δ knockout mice have shown a direct ability of PPARβ/δ to regulate angiogenesis in vitro and in vivo in animal models.
PPARβ/δ ligands induce the proangiogenic growth factor VEGF in many cells and tissues, though its actions in the eye are not known.
However, virtually, all tissue components of the eye express PPARβ/δ.
Both angiogenesis and in particular VEGF are not only critical for the development of the retina, but they are also a central component in many common pathologies of the eye, including diabetic retinopathy and age-related macular degeneration, the most common causes of blindness in the Western world.
This review, therefore, will discuss the recent evidence of PPARβ/δ-mediated angiogenesis and VEGF release in the context of ocular disorders.
American Psychological Association (APA)
Bishop-Bailey, David. 2008. A Role for PPARβδ in Ocular Angiogenesis. PPAR Research،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988241
Modern Language Association (MLA)
Bishop-Bailey, David. A Role for PPARβδ in Ocular Angiogenesis. PPAR Research No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988241
American Medical Association (AMA)
Bishop-Bailey, David. A Role for PPARβδ in Ocular Angiogenesis. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988241