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No Incidence of BRAF Mutations in Salivary Gland Carcinomas—Implications for Anti-EGFR Therapies
Joint Authors
Dahse, Regine
Kosmehl, Hartwig
Berndt, Alexander
Kromeyer-Hauschild, Katrin
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-09
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
BRAF is the main effector of KRAS in the RAS-RAF-MAPK axis, a signaling pathway downstream of EGFR.
The activation of this cascade is an important pathway in cancer development and is considered a key pathway for therapeutic molecules.
Recent studies in metastatic colorectal cancer found that an oncogenic activation of BRAF by a point mutation in exon 15 (V600E) could bypass the EGFR-initiated signaling cascade with the effect that patients bearing the mutant BRAF allele are not likely to benefit from EGFR-targeted therapies.
We designed an allele-specific PCR and screened 65 salivary gland carcinoma (SGC) of the main histopathological types for the BRAF V600E mutation.
All 65 SGC in this cohort (100%) presented the BRAF wildtype.
In a previous study, we found a KRAS wildtype in 98.5% of SGC.
These findings imply that SGC rarely acquires mutations that result in a constitutive activation of the signaling cascade downstream of EGFR and this pleads in favor of further therapeutic trials with EGFR-targeting monoclonal antibodies.
American Psychological Association (APA)
Dahse, Regine& Kromeyer-Hauschild, Katrin& Berndt, Alexander& Kosmehl, Hartwig. 2009. No Incidence of BRAF Mutations in Salivary Gland Carcinomas—Implications for Anti-EGFR Therapies. BioMed Research International،Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-988382
Modern Language Association (MLA)
Dahse, Regine…[et al.]. No Incidence of BRAF Mutations in Salivary Gland Carcinomas—Implications for Anti-EGFR Therapies. BioMed Research International No. 2009 (2009), pp.1-3.
https://search.emarefa.net/detail/BIM-988382
American Medical Association (AMA)
Dahse, Regine& Kromeyer-Hauschild, Katrin& Berndt, Alexander& Kosmehl, Hartwig. No Incidence of BRAF Mutations in Salivary Gland Carcinomas—Implications for Anti-EGFR Therapies. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-3.
https://search.emarefa.net/detail/BIM-988382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988382