Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study
Joint Authors
Wang, Xun
Chen, Dafang
Hu, Yonghua
Liang, Mingbin
Fang, Zhian
Wang, Lihua
Yang, Fan
Li, Jin
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Preterm delivery (PTD) is a complicated perinatal adverse event.
We were interested in association of G308A polymorphism in tumor necrosis factor-α (TNF-α) gene with PTD; so we conducted a genetic epidemiology study in Anqing City, Anhui Province, China.
Case families and control families were all collected between July 1999 and June 2002.
To control potential population stratification as we could, all eligible subjects were ethnic Han Chinese.
250 case families and 247 control families were included in data analysis.
A hybrid design which combines case-parent triads and control parents was employed, to test maternal-fetal genotype (MFG) incompatibility.
The method is based on a log-linear modeling approach.
In summary, we found that when the mother's or child's genotype was G/A, there was a reduced risk of PTD; however when the mother's or child's genotype was genotype A/A, there was a relatively higher risk of PTD.
Combined maternal-fetal genotype GA/GA showed the most reduced risk of PTD.
Comparison of the LRTs showed that the model with maternal-fetal genotype effects fits significantly better than the model with only maternal and fetal genotype main effects (log-likelihood = −719.4, P=.023, significant at 0.05 level).
That means that the combined maternal-fetal genotype incompatibility was significantly associated with PTD.
The model with maternal-fetal genotype effects can be considered a gene-gene interaction model.
We claim that both maternal effects and fetal effects should be considered together while investigating genetic factors of certain perinatal diseases.
American Psychological Association (APA)
Liang, Mingbin& Wang, Xun& Li, Jin& Yang, Fan& Fang, Zhian& Wang, Lihua…[et al.]. 2010. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988893
Modern Language Association (MLA)
Liang, Mingbin…[et al.]. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988893
American Medical Association (AMA)
Liang, Mingbin& Wang, Xun& Li, Jin& Yang, Fan& Fang, Zhian& Wang, Lihua…[et al.]. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988893