InductionEngineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific CD8+ Cytotoxic T Cell Clones for Adoptive Immunotherapy
Joint Authors
Bricl, Irena
Zorec, Robert
Jeras, Matjaž
Švajger, Urban
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-22
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Adoptive transfer of effector antigen-specific immune cells is becoming a promising treatment option in allogeneic transplantation, infectious diseases, cancer, and autoimmune disorders.
Within this context, the important role of CD8+ cytotoxic T cells (CTLs) is objective of intensive studies directed to their in vivo and ex vivo induction, detection, selection, expansion, and therapeutic effectiveness.
Additional questions that are being addressed by the scientific community are related to the establishment and maintenance of their longevity and memory state as well as to defining critical conditions underlying their transitions between discrete, but functionally different subtypes.
In this article we review and comment latest approaches and techniques used for preparing large amounts of antigen-specific CTLs, suitable for clinical use.
American Psychological Association (APA)
Jeras, Matjaž& Bricl, Irena& Zorec, Robert& Švajger, Urban. 2010. InductionEngineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific CD8+ Cytotoxic T Cell Clones for Adoptive Immunotherapy. BioMed Research International،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989074
Modern Language Association (MLA)
Jeras, Matjaž…[et al.]. InductionEngineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific CD8+ Cytotoxic T Cell Clones for Adoptive Immunotherapy. BioMed Research International No. 2010 (Dec. 2010), pp.1-15.
https://search.emarefa.net/detail/BIM-989074
American Medical Association (AMA)
Jeras, Matjaž& Bricl, Irena& Zorec, Robert& Švajger, Urban. InductionEngineering, Detection, Selection, and Expansion of Clinical-Grade Human Antigen-Specific CD8+ Cytotoxic T Cell Clones for Adoptive Immunotherapy. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-989074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989074