Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4
Joint Authors
Fu, Xiao-Lan
Wang, Jing-Xue
Huang, Ze-Min
Ni, Bing
Jia, Zheng-Cai
Tang, Jun
Wu, Yu-Zhang
Tian, Yi
Source
Journal of Immunology Research
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
MAGE-A antigens belong to cancer/testis (CT) antigens that are expressed in tumors but not in normal tissues except testis and placenta.
MAGE-A antigens and their epitope peptides have been used in tumor immunotherapy trials.
MAGE-A4 antigen is extensively expressed in various histological types of tumors, so it represents an attractive target for tumor immunotherapy.
In this study, we predicted HLA-A∗0201-restricted cytotoxic T lymphocyte (CTL) epitopes of MAGE-A4, followed by peptide/HLA-A∗0201 affinity and complex stability assays.
Of selected four peptides (designated P1, P2, P3, and P4), P1 (MAGE-A4286-294, KVLEHVVRV) and P3 (MAGE-A4272-280, FLWGPRALA) could elicit peptide-specific CTLs both in vitro from HLA-A∗0201-positive PBMCs and in HLA-A∗0201/Kb transgenic mice.
And the induced CTLs could lyse target cells in an HLA-A∗0201-restricted fashion, demonstrating that the two peptides are HLA-A∗0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination.
American Psychological Association (APA)
Jia, Zheng-Cai& Ni, Bing& Huang, Ze-Min& Tian, Yi& Tang, Jun& Wang, Jing-Xue…[et al.]. 2010. Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989322
Modern Language Association (MLA)
Jia, Zheng-Cai…[et al.]. Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4. Journal of Immunology Research No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-989322
American Medical Association (AMA)
Jia, Zheng-Cai& Ni, Bing& Huang, Ze-Min& Tian, Yi& Tang, Jun& Wang, Jing-Xue…[et al.]. Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-989322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-989322